The prediction of a mutation in the absence of other subunits of RNA polymerase that leads to the binding of σ to the -10 regions should be determined. Concept introduction: Non-competitive inhibition can be defined as a type of enzyme inhibition. In this inhibition, usually, the inhibitor diminishes the enzyme activity. The inhibitor gets fixed alike the normal substrate does to the enzyme. It occurs even if it has been previously bound or not to the substrate. Unlike competitive inhibition, non-competitive inhibition cannot be overcome with the additional substrate.

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Chapter 29, Problem 6P

Interpretation Introduction

Interpretation:

The prediction of a mutation in the absence of other subunits of RNA polymerase that leads to the binding of σ to the -10 regions should be determined.

Concept introduction:

Non-competitive inhibition can be defined as a type of enzyme inhibition. In this inhibition, usually, the inhibitor diminishes the enzyme activity. The inhibitor gets fixed alike the normal substrate does to the enzyme. It occurs even if it has been previously bound or not to the substrate. Unlike competitive inhibition, non-competitive inhibition cannot be overcome with the additional substrate.

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