BIOLOGY: CONCEPTS AND INVEST. ACCESS
5th Edition
ISBN: 9781264448678
Author: Hoefnagels
Publisher: MCG
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Chapter 28.2, Problem 4MC
Summary Introduction
To determine:
The reason for slow activity of steroid hormone.
Concept introduction:
Steroid hormones are synthesized from cholesterol and released immediately in the blood stream (the hormone circulates with blood by binding to plasma protein as it is insoluble in blood). They are fat soluble small molecules and can pass through the cell membrane.
Example; sex hormone (testosterone and estrogen), aldosterone and cortisol.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 28 Solutions
BIOLOGY: CONCEPTS AND INVEST. ACCESS
Ch. 28.1 - Prob. 1MCCh. 28.1 - Prob. 2MCCh. 28.1 - Prob. 3MCCh. 28.1 - Prob. 4MCCh. 28.1 - Prob. 5MCCh. 28.2 - Prob. 1MCCh. 28.2 - Describe the locations of the receptors that bind...Ch. 28.2 - Prob. 3MCCh. 28.2 - Prob. 4MCCh. 28.3 - Prob. 1MC
Ch. 28.3 - Prob. 2MCCh. 28.4 - Prob. 1MCCh. 28.4 - Prob. 2MCCh. 28.4 - Prob. 3MCCh. 28.4 - Prob. 4MCCh. 28.4 - Prob. 5MCCh. 28.5 - Prob. 1MCCh. 28.5 - Prob. 2MCCh. 28.6 - Prob. 1MCCh. 28.6 - Prob. 2MCCh. 28 - The effect of a water-soluble peptide hormone such...Ch. 28 - Prob. 2MCQCh. 28 - Prob. 3MCQCh. 28 - Prob. 4MCQCh. 28 - Prob. 5MCQCh. 28 - Prob. 6MCQCh. 28 - To increase male fertility, it would be logical to...Ch. 28 - How does the endocrine system interact with the...Ch. 28 - Prob. 2WIOCh. 28 - Sketch the mechanisms of water-soluble and...Ch. 28 - Give two examples of hormones counteracting the...Ch. 28 - Alcohol and caffeine inhibit the effects of...Ch. 28 - Prob. 6WIOCh. 28 - Prob. 7WIOCh. 28 - Prob. 8WIOCh. 28 - How might insulin-producing stem cells...Ch. 28 - Prob. 10WIOCh. 28 - Prob. 1PITCh. 28 - Connect each hormone discussed in this chapter to...Ch. 28 - Prob. 3PIT
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