Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 28, Problem 29CQ
Summary Introduction
To explain: The reason why RNAi would be a less-efficient mechanism for the expression of specific genes if Dicer hydrolyzes the double-stranded RNA for every 11 bp rather than for every 22 bp.
Introduction: RNA interference (RNAi) is the pathway that is involved in the sequence of specific post-transcriptional gene regulation. After the initial processing of pre-miRNAs in the nucleus, it is transported into the cytoplasm. Here, Dicer cleaves and generates microRNAs (miRNAs) and short-interfering RNAs (siRNAs). These double-stranded RNA products are associated with the Argonaute proteins. It is done such that one strand is chosen to guide the sequence-specific silencing of the complementary target mRNAs.
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Chapter 28 Solutions
Fundamentals of Biochemistry: Life at the Molecular Level
Ch. 28 - Prob. 1ECh. 28 - 2. Explain why the organization of genes in...Ch. 28 - 3. The genome of Daphnia pulex, a small freshwater...Ch. 28 - 4. The marine alga Ostreococcus tauri has an...Ch. 28 - Prob. 5ECh. 28 - Prob. 6ECh. 28 - Prob. 7ECh. 28 - Prob. 8ECh. 28 - 9. Why do E. coli cells with a defective lacZ gene...Ch. 28 - 10. Describe the probable genetic defect that...
Ch. 28 - Prob. 11ECh. 28 - 12. Predict the effect of deleting the leader...Ch. 28 - Prob. 13ECh. 28 - Prob. 14ECh. 28 - Prob. 15ECh. 28 - Prob. 16ECh. 28 - 17. Explain why natural selection has favored the...Ch. 28 - Prob. 18ECh. 28 - Prob. 19ECh. 28 - Prob. 20ECh. 28 - Prob. 21ECh. 28 - 22. During apoptosis, phosphatidylserine (Section...Ch. 28 - 23. In Drosophila, an esc? homozygote develops...Ch. 28 - 24. Describe the appearance of a Drosophila...Ch. 28 - 25. Red-green color blindness is caused by an...Ch. 28 - 26. Why is transcriptionally active chromatin ~10...Ch. 28 - 27. Explain why a deficiency of the vitamin folic...Ch. 28 - 28. Proliferation and differentiation of T and B...Ch. 28 - 29. Explain why RNAi would be a less efficient...Ch. 28 - Prob. 30CQCh. 28 - Prob. 31CQCh. 28 - MORE TO EXPLORE Even relatively compact bacterial...
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