Anatomy & Physiology: The Unity of Form and Function
8th Edition
ISBN: 9781259277726
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 27.2, Problem 1AYLO
Anatomy and functions of the scrotum and spermatic cord
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 27 Solutions
Anatomy & Physiology: The Unity of Form and Function
Ch. 27.1 - Essential characteristics of sexual reproduction;...Ch. 27.1 - Multiple functions of the male and female...Ch. 27.1 - Prob. 3AYLOCh. 27.1 - Prob. 4AYLOCh. 27.1 - Prob. 5AYLOCh. 27.1 - Fates of the mesonephric and paramesonephric ducts...Ch. 27.1 - Structures of the embryonic genital tubercle,...Ch. 27.1 - Prob. 8AYLOCh. 27.2 - Anatomy and functions of the scrotum and spermatic...Ch. 27.2 - Prob. 2AYLO
Ch. 27.2 - Prob. 3AYLOCh. 27.2 - The germinal epithelium of the seminiferous...Ch. 27.2 - The arterial supply and venous drainage of the...Ch. 27.2 - Gross anatomy of the epididymis; the series of...Ch. 27.2 - Three sets of male accessory glands: their...Ch. 27.2 - Prob. 8AYLOCh. 27.2 - Prob. 9AYLOCh. 27.3 - Definitions of puberty and adolescence; the...Ch. 27.3 - Prob. 2AYLOCh. 27.3 - Prob. 3AYLOCh. 27.3 - Prob. 4AYLOCh. 27.3 - Changes in the levels of testosterone, inhibin,...Ch. 27.3 - Prob. 6AYLOCh. 27.4 - Prob. 1AYLOCh. 27.4 - Why meiosis is necessary in sexually reproducing...Ch. 27.4 - Prob. 3AYLOCh. 27.4 - Prob. 4AYLOCh. 27.4 - The origin of primordial germ cells, their...Ch. 27.4 - Prob. 6AYLOCh. 27.4 - Prob. 7AYLOCh. 27.4 - Prob. 8AYLOCh. 27.4 - Prob. 9AYLOCh. 27.4 - Prob. 10AYLOCh. 27.4 - Prob. 11AYLOCh. 27.5 - Blood vessels of the penis and how they function...Ch. 27.5 - Prob. 2AYLOCh. 27.5 - Prob. 3AYLOCh. 27.5 - The mechanism of erection including the roles of...Ch. 27.5 - The physiological state of the male in the plateau...Ch. 27.5 - Prob. 6AYLOCh. 27.5 - Prob. 7AYLOCh. 27 - crypto-Ch. 27 - Prob. 2BYMVCh. 27 - Prob. 3BYMVCh. 27 - Prob. 4BYMVCh. 27 - Prob. 5BYMVCh. 27 - meio-Ch. 27 - Prob. 7BYMVCh. 27 - Prob. 8BYMVCh. 27 - someCh. 27 - Prob. 10BYMVCh. 27 - Prob. 1TYCCh. 27 - Prob. 2TYCCh. 27 - Prob. 3TYCCh. 27 - Why is it possible for spermatogonia to be outside...Ch. 27 - A 68-year-old man taking medication for...Ch. 27 - Testosterone is secreted by the nurse cells of the...Ch. 27 - Prob. 2WWTSCh. 27 - Prob. 3WWTSCh. 27 - Prob. 4WWTSCh. 27 - A high testosterone level makes a fetus develop a...Ch. 27 - Prob. 6WWTSCh. 27 - Prob. 7WWTSCh. 27 - Prob. 8WWTSCh. 27 - Male menopause is the cessation of sperm...Ch. 27 - Prob. 10WWTSCh. 27 - The ductus deferens develops from the _______.of...Ch. 27 - The protein that clots and causes the stickiness...Ch. 27 - The expulsion of semen occurs when the...Ch. 27 - Prob. 4TYRCh. 27 - The penis is attached to the pubic arch by crura...Ch. 27 - The first hormone secreted at the onset of puberty...Ch. 27 - Prob. 7TYRCh. 27 - Four spermatozoa arise from each a. primordial...Ch. 27 - The point in meiosis at which sister chromatids...Ch. 27 - Blood is forced out of the penile lacunae by...Ch. 27 - Prob. 11TYRCh. 27 - Prob. 12TYRCh. 27 - Prob. 13TYRCh. 27 - Prob. 14TYRCh. 27 - Prob. 15TYRCh. 27 - Prob. 16TYRCh. 27 - Prob. 17TYRCh. 27 - Prob. 18TYRCh. 27 - Erection of the penis occurs when nitric oxide...Ch. 27 - A sperm penetrates the egg by means of enzymes in...Ch. 27 - Prob. 1BYGOCh. 27 - Prob. 2BYGOCh. 27 - Prob. 3BYGOCh. 27 - Prob. 4BYGOCh. 27 - Prob. 5BYGOCh. 27 - Prob. 6BYGOCh. 27 - Prob. 7BYGOCh. 27 - Prob. 8BYGOCh. 27 - Prob. 9BYGOCh. 27 - Prob. 10BYGOCh. 27 - Prob. 11BYGOCh. 27 - Prob. 12BYGOCh. 27 - Prob. 13BYGOCh. 27 - Prob. 14BYGOCh. 27 - Prob. 15BYGOCh. 27 - Prob. 16BYGOCh. 27 - Prob. 17BYGOCh. 27 - Prob. 18BYGOCh. 27 - Prob. 19BYGOCh. 27 - Prob. 20BYGO
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