A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed. Concept introduction: The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH. To propose: A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

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Answer 1

Question

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

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Answer 2

Question

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

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Answer 3

Question

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

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Answer 4

Question

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

Expert Solution & Answer

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Answer 5

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

Answer 6

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

Answer 7

Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.

Answer 8

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Answer 10

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Answer 11

Ch. 26.1 - How many of the -amino acids shown in Table 26-1...Ch. 26.1 - Prob. 2P Ch. 26.1 - Prob. 3P Ch. 26.2 - Hemoglobin has pI=6.8. Does hemoglobin have a net...Ch. 26.3 - Show how you could prepare the following -amino...Ch. 26.3 - What alkyl halides would you use to prepare the...Ch. 26.3 - Prob. 7P Ch. 26.4 - There are six isomeric tripeptides that contain...Ch. 26.4 - Draw the structure of M-P-V-G, and indicate its...Ch. 26.5 - Prob. 10P

Solution Summary: The author proposes the reductive amination of lysine with - ketoglutarate to yield saccharopine.

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