EBK ORGANIC CHEMISTRY

9th Edition

ISBN: 8220100591310

Author: McMurry

Publisher: CENGAGE L

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Neutral Amino Acids

Amino acids which do not have any charge on them are neutral amino acids.

Globular Protein

The globular proteins refer to the shape of protein specifically spherical in nature apart from spherical form fibrous, disordered and membrane-bound proteins exist. These globular proteins are miscible in water and form a colloidal solution rather than …

Dimer

Dimers are basic organic compounds, which are derivates of oligomers. It is formed by the combination of two monomers which could potentially be strong or weak and in most cases covalent or intermolecular in nature. Identical monomers are called homodime…

Dipeptide

A dipeptide is considered a mixture of two distinct amino acids. Since the amino acids are distinct, based on their composition, two dipeptide's isomers can be produced. Various dipeptides are biologically essential and are therefore crucial to industry.

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Textbook Question

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Chapter 26.SE, Problem 49AP

Leuprolide is a synthetic nonapeptide used to treat both endometriosis in women and prostate cancer in men.

Chapter 26.SE, Problem 49AP, Leuprolide is a synthetic nonapeptide used to treat both endometriosis in women and prostate cancer

(a) Both C-terminal and N-terminal amino acids in leuprolide have been structurally modified. Identify the modifications.

(b) One of the nine amino acids in leuprolide has d stereochemistry rather than the usual L. Which one?

(d) What charge would you expect leuprolide to have at neutral pH?

Expert Solution & Answer

Chapter 26 Solutions

EBK ORGANIC CHEMISTRY

Ch. 26.1 - How many of the -amino acids shown in Table 26-1...Ch. 26.1 - Prob. 2P Ch. 26.1 - Prob. 3P Ch. 26.2 - Hemoglobin has pI=6.8. Does hemoglobin have a net...Ch. 26.3 - Show how you could prepare the following -amino...Ch. 26.3 - What alkyl halides would you use to prepare the...Ch. 26.3 - Prob. 7P Ch. 26.4 - There are six isomeric tripeptides that contain...Ch. 26.4 - Draw the structure of M-P-V-G, and indicate its...Ch. 26.5 - Prob. 10P

Ch. 26.5 - Prob. 11P Ch. 26.6 - The octapeptide angiotensin II has the sequence...Ch. 26.6 - Prob. 13P Ch. 26.6 - Prob. 14P Ch. 26.6 - Give the amino acid sequence of hexapeptides that...Ch. 26.7 - Prob. 16P Ch. 26.7 - Write all five steps required for the synthesis of...Ch. 26.10 - Prob. 18P Ch. 26.SE - Identify the following amino acids:Ch. 26.SE - Prob. 20VC Ch. 26.SE - Isoleucine and threonine are the only two amino...Ch. 26.SE - Prob. 22VC Ch. 26.SE - Give the sequence of the following tetrapeptide:Ch. 26.SE - Prob. 24MP Ch. 26.SE - The chloromethylated polystyrene resin used for...Ch. 26.SE - Prob. 26MP Ch. 26.SE - Prob. 27MP Ch. 26.SE - Prob. 28MP Ch. 26.SE - Except for cysteine, only S amino acids occur in...Ch. 26.SE - Prob. 30AP Ch. 26.SE - Prob. 31AP Ch. 26.SE - Show the structures of the following amino acids...Ch. 26.SE - Prob. 33AP Ch. 26.SE - Using both three- and one-letter codes for amino...Ch. 26.SE - Prob. 35AP Ch. 26.SE - Show how you could use the acetamidomalonate...Ch. 26.SE - Prob. 37AP Ch. 26.SE - Show how you could prepare the following amino...Ch. 26.SE - Prob. 39AP Ch. 26.SE - Predict the product of the reaction of valine with...Ch. 26.SE - Prob. 41AP Ch. 26.SE - Prob. 42AP Ch. 26.SE - Propose two structures for a tripeptide that gives...Ch. 26.SE - Show the steps involved in a synthesis of...Ch. 26.SE - Prob. 45AP Ch. 26.SE - Prob. 46AP Ch. 26.SE - Prob. 47AP Ch. 26.SE - Which of the following amino acids are more likely...Ch. 26.SE - Leuprolide is a synthetic nonapeptide used to...Ch. 26.SE - The -helical parts of myoglobin and other proteins...Ch. 26.SE - Prob. 51AP Ch. 26.SE - Cytochrome c is an enzyme found in the cells of...Ch. 26.SE - Prob. 53AP Ch. 26.SE - Prob. 54AP Ch. 26.SE - Prob. 55AP Ch. 26.SE - What is the structure of a nonapeptide that gives...Ch. 26.SE - Oxytocin, a nonapeptide hormone secreted by the...Ch. 26.SE - Aspartame, a nonnutritive sweetener marketed under...Ch. 26.SE - Prob. 59AP Ch. 26.SE - Prob. 60AP Ch. 26.SE - Prob. 61AP Ch. 26.SE - Prob. 62AP

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Solution Summary: The author explains the structure of leuprolide using one letter and three letter abbreviations and the charge it is expected to have at neutral pH.

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