Chapter 26.SE, Problem 61AP

Interpretation Introduction

Interpretation:

A mechanism for the formation of a 4-methylidene-5-imidazolone (MIO) by cyclization of a segment of the peptide chain in the histidine ammonia lysase enzyme is to be proposed.

Concept introduction:

The steps involved in the formation of a 4-methylidene-5-imidazolone (MIO) by cyclization of a segment of the peptide chain in the histidine ammonia lysase enzyme are i) Nucleophilic attack of N on the carbonyl carbon ii) exchange of a proton iii) Elimination of water iv) Another elimination of water.

To propose:

A mechanism for the formation of a 4-methylidene-5-imidazolone (MIO) by cyclization of a segment of the peptide chain in the histidine ammonia lysase enzyme.