Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.