Microbiology: An Evolving Science (Fourth Edition)
Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 26.7, Problem 3TQ
Summary Introduction

To review:

The use of botulism toxin for the treatment of tetanus.

Introduction:

Spastic paralysis refers to increased tendon flexes and tonic spasm caused by the toxin of Clostridium tetani. Flaccid paralysis refers to a decreased muscle tone caused by Clostridium botulinum. The structure of both the toxins is similar and comprises two peptides containing heavy and light chains. These chains are attached by a disulphide bond. The heavy chain has a binding and translocation domain, while the light chain has a catalytic domain.

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