The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined. Concept Introduction: In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has − CH 2 Cl groups at the surface. Nucleophilic substitution of the chlorine in the − CH 2 Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

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Answer 1

Question

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

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Answer 2

Question

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

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Answer 3

Question

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

Expert Solution & Answer

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Answer 4

Question

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

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Answer 5

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

Answer 6

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

Answer 7

Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of Phe-Gly by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has −CH2Cl groups at the surface.

Nucleophilic substitution of the chlorine in the −CH2Cl group by the carboxylate of an N-Boc-protected C-terminal amino acid anchors it to the polymer, protecting the C-terminus.

Answer 8

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Answer 9

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Answer 10

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Answer 11

Ch. 26.1 - Prob. 1P Ch. 26.2 - Prob. 2P Ch. 26.2 - Prob. 3P Ch. 26.3 - Prob. 4P Ch. 26.3 - Prob. 5P Ch. 26.4 - Prob. 6P Ch. 26.4 - Prob. 7P Ch. 26.4 - Prob. 8P Ch. 26.5 - Prob. 9P Ch. 26.6 - Prob. 10P

Solution Summary: The author explains the steps in the preparation of Phe-Gly by the Merrifield method.

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Chapter 26 Solutions