ORGANIC CHEMISTRY (LL)-W/SOLN.>CUSTOM<
ORGANIC CHEMISTRY (LL)-W/SOLN.>CUSTOM<
10th Edition
ISBN: 9781259972348
Author: Carey
Publisher: MCG CUSTOM
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Chapter 26.4, Problem 7P
Interpretation Introduction

Interpretation:

A retrosynthetic analysis to plan a synthesis of isoleucine from 2-methyl-1-butanol is to be used and equations for the synthesis are to be written.

Concept Introduction:

Amino acids can be synthesized by the reaction of an aldehyde with NH4Cl and NaCN. It is known as the Strecker synthesis.

This is a double nucleophilic addition reaction that converts the aldehyde to an amino acid having one more carbon atom.

Hydrolysis of the nitrile group converts the nitrile to the carboxylic acid group.

Aldehydes can be obtained by the oxidation of primary alcohols with pyridinium chlorochromate. This reagent stops the oxidation at the aldehyde stage.

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