How it is possible for the immune system to respond quickly during the second attack of a pathogen. Introduction: After the first attack, memory immune cells are created and constantly circulating in the body.

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Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

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Answer 2

Question

Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Answer 6

Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Answer 7

Chapter 26, Problem 8SA

Summary Introduction

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Answer 8

Expert Solution & Answer

Answer 9

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Answer 11

Ch. 26 - Prob. 1SA Ch. 26 - Prob. 2SA Ch. 26 - Prob. 3SA Ch. 26 - Prob. 4SA Ch. 26 - Prob. 5SA Ch. 26 - Prob. 6SA Ch. 26 - Prob. 7SA Ch. 26 - Prob. 8SA Ch. 26 - Prob. 9SA Ch. 26 - Prob. 10SA

How it is possible for the immune system to respond quickly during the second attack of a pathogen. Introduction: After the first attack, memory immune cells are created and constantly circulating in the body.

Solution Summary: The author analyzes how the immune system responds quickly during the second attack of a pathogen.

Concept explainers

Videos

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.

Want to see the full answer?

Chapter 26 Solutions

How it is possible for the immune system to respond quickly during the second attack of a pathogen. Introduction: After the first attack, memory immune cells are created and constantly circulating in the body.

Solution Summary: The author analyzes how the immune system responds quickly during the second attack of a pathogen.

Concept explainers

Videos

To analyze: How it is possible for the immune system to respond quickly during the second attack of a pathogen. Introduction: After the first attack, memory immune cells are created and constantly circulating in the body.

Want to see the full answer?

Chapter 26 Solutions

To analyze:

How it is possible for the immune system to respond quickly during the second attack of a pathogen.

Introduction:

After the first attack, memory immune cells are created and constantly circulating in the body.