Introduction to General, Organic and Biochemistry
11th Edition
ISBN: 9781285869759
Author: Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher: Cengage Learning
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Chapter 26, Problem 26.38P
Explain what happens to the fMet initially put at
the N-terminus.
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need help please and thanks dont understand only need help with C-F
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal…
Please correct answer and don't used hand raiting
need help please and thanks dont understand a-b
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
Chapter 26 Solutions
Introduction to General, Organic and Biochemistry
Ch. 26.2 - Problem 26-1 DNA is highly condensed in the...Ch. 26.4 - Prob. 26.2PCh. 26.6 - Prob. 26.3PCh. 26.8 - Prob. 26.4PCh. 26 - Does the term gene expression refer to: (a)...Ch. 26 - Prob. 26.6PCh. 26 - Where does most Of the translation occur in a...Ch. 26 - What is the function of RNA polymerase?Ch. 26 - What is the role of helicase in transcription?Ch. 26 - Prob. 26.10P
Ch. 26 - Prob. 26.11PCh. 26 - Prob. 26.12PCh. 26 - Prob. 26.13PCh. 26 - Prob. 26.14PCh. 26 - What is the difference in the requirement for a...Ch. 26 - What are the different names used for the two...Ch. 26 - Prob. 26.17PCh. 26 - Prob. 26.18PCh. 26 - Prob. 26.19PCh. 26 - Prob. 26.20PCh. 26 - Where are the codons located?Ch. 26 - What are the two most important sites on tRNA...Ch. 26 - Prob. 26.23PCh. 26 - (a) If a codon is GCU, what is the anticodon? (b)...Ch. 26 - If a segment of DNA is 981 units long, how many...Ch. 26 - In what sense does the universality of the genetic...Ch. 26 - Prob. 26.27PCh. 26 - Prob. 26.28PCh. 26 - A genetic code in which two bases encode a single...Ch. 26 - What is meant by the genetic code being continuous...Ch. 26 - Prob. 26.31PCh. 26 - Prob. 26.32PCh. 26 - Prob. 26.33PCh. 26 - Prob. 26.34PCh. 26 - Prob. 26.35PCh. 26 - What are the stages of protein synthesis?Ch. 26 - Prob. 26.37PCh. 26 - Explain what happens to the fMet initially put at...Ch. 26 - Prob. 26.39PCh. 26 - Why is amino acid activation called the second...Ch. 26 - Prob. 26.41PCh. 26 - Prob. 26.42PCh. 26 - Prob. 26.43PCh. 26 - Prob. 26.44PCh. 26 - Prob. 26.45PCh. 26 - Prob. 26.46PCh. 26 - Prob. 26.47PCh. 26 - What kind of interactions exist between metal-...Ch. 26 - Prob. 26.49PCh. 26 - Prob. 26.50PCh. 26 - Prob. 26.51PCh. 26 - Prob. 26.52PCh. 26 - Prob. 26.53PCh. 26 - Prob. 26.54PCh. 26 - Prob. 26.55PCh. 26 - Prob. 26.56PCh. 26 - Prob. 26.57PCh. 26 - Prob. 26.58PCh. 26 - Prob. 26.59PCh. 26 - Prob. 26.60PCh. 26 - Prob. 26.61PCh. 26 - Prob. 26.62PCh. 26 - Prob. 26.63PCh. 26 - Prob. 26.64PCh. 26 - Prob. 26.65PCh. 26 - Prob. 26.66PCh. 26 - Prob. 26.67PCh. 26 - Prob. 26.68PCh. 26 - Prob. 26.69PCh. 26 - Prob. 26.70PCh. 26 - Prob. 26.71PCh. 26 - Prob. 26.72PCh. 26 - Prob. 26.73PCh. 26 - Prob. 26.74PCh. 26 - Prob. 26.75PCh. 26 - (Chemical Connections 26D) If an mRNA codon has...Ch. 26 - Prob. 26.77PCh. 26 - Prob. 26.78PCh. 26 - Prob. 26.79PCh. 26 - Prob. 26.80PCh. 26 - Prob. 26.81PCh. 26 - Prob. 26.82PCh. 26 - Prob. 26.83PCh. 26 - Prob. 26.84PCh. 26 - Prob. 26.85PCh. 26 - Prob. 26.86PCh. 26 - Prob. 26.87PCh. 26 - Prob. 26.88PCh. 26 - Prob. 26.89PCh. 26 - Prob. 26.90PCh. 26 - Prob. 26.91PCh. 26 - Prob. 26.92PCh. 26 - Is there any way to prevent a hereditary disease?...Ch. 26 - Prob. 26.94PCh. 26 - Prob. 26.95PCh. 26 - Prob. 26.96PCh. 26 - Glycine, alanine, and valine are classified as...Ch. 26 - Prob. 26.98PCh. 26 - Which polypeptide is coded for by the mRNA...Ch. 26 - -100 A new endonuclease is found. It cleaves...
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