ANATOMY+PHYSIOLOGY
4th Edition
ISBN: 9781260265217
Author: McKinley
Publisher: RENT MCG
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Question
Chapter 25.5, Problem 18WDYL
Summary Introduction
To analyze:
The reason why respiration does not normally maintain acid-base balance.
Introduction:
Respiration is associated with breathing mechanisms. This involves the inhalation of oxygen and exhalation of carbon dioxide. The respiration process also maintains the homeostasis between the respiratory gases.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 25 Solutions
ANATOMY+PHYSIOLOGY
Ch. 25.1 - Prob. 1WDYLCh. 25.1 - Which ions are more prevalent in the intracellular...Ch. 25.1 - What is the major distinction in the chemical...Ch. 25.1 - Prob. 4WDYLCh. 25.2 - What are the two major sources of fluid intake?...Ch. 25.2 - How would you distinguish fluid deficiency from...Ch. 25.2 - Prob. 7WDYLCh. 25.2 - Which of these four hormonesangiotensin II,...Ch. 25.3 - Why do electrolytes exert a greater osmotic...Ch. 25.3 - Prob. 10WDYL
Ch. 25.4 - Prob. 11WDYLCh. 25.4 - How does the homeostatic system involving ADH...Ch. 25.4 - Prob. 13WDYLCh. 25.4 - Prob. 14WDYLCh. 25.5 - What is meant by acid-base balance?Ch. 25.5 - How are fixed acids distinguished from volatile...Ch. 25.5 - How do the kidneys regulate fixed acids to help...Ch. 25.5 - Prob. 18WDYLCh. 25.5 - What are the three chemical buffering systems, and...Ch. 25.5 - Prob. 20WDYLCh. 25.6 - Prob. 21WDYLCh. 25.6 - Prob. 22WDYLCh. 25.6 - Prob. 23WDYLCh. 25.6 - Prob. 24WDYLCh. 25.6 - Prob. 25WDYLCh. 25.6 - Prob. 26WDYLCh. 25 - Prob. 1DYKBCh. 25 - _____ 2. The fluid compartment with the largest...Ch. 25 - _____3. Which of the following would result in...Ch. 25 - _____4. If an individual has decreased saliva...Ch. 25 - _____5. Which hormone decreases total body fluid,...Ch. 25 - Which of the following describes an electrolyte?...Ch. 25 - Prob. 7DYKBCh. 25 - Prob. 8DYKBCh. 25 - Which of the following is not a chemical buffer in...Ch. 25 - Prob. 10DYKBCh. 25 - List the three variables that determine the...Ch. 25 - Describe the movement of water between the...Ch. 25 - Prob. 13DYKBCh. 25 - Explain the homeostatic system involving the renin...Ch. 25 - Describe how ANP is regulated and how it opposes...Ch. 25 - Describe the functions of Na+ and how it is...Ch. 25 - Describe what occurs in the kidney to maintain...Ch. 25 - Prob. 18DYKBCh. 25 - List the three chemical buffers, and describe how...Ch. 25 - Describe respiratory acidosis and its...Ch. 25 - Maria brings her baby to the emergency room. She...Ch. 25 - Prob. 2CALCh. 25 - Prob. 3CALCh. 25 - Harold has been suffering from diabetes mellitus...Ch. 25 - Prob. 5CALCh. 25 - Morgan is a nurse at the local hospital. She...Ch. 25 - Ms. Taylor, 68 years old, has been vomiting for 2...Ch. 25 - Prob. 3CSL
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