Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Chapter 25.3, Problem 1CR
Summary Introduction
The ability of the pathogen to cause an infectious disease is measured in terms of pathogenicity and virulence. The cumulative effect of interaction of the pathogen with host which helps to measure the pathogenicity is termed as virulence. Virulence would be different for different microorganisms and will vary from one strain to another strain. Virulence can be quantified in terms of LD50 by the presence of lethal pathogen and a suitable animal model.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 25 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 25.1 - What event is required but not sufficient to cause...Ch. 25.1 - Prob. 2MQCh. 25.1 - Prob. 1CRCh. 25.2 - Prob. 1MQCh. 25.2 - Prob. 2MQCh. 25.2 - Prob. 3MQCh. 25.2 - Prob. 1CRCh. 25.3 - What are virulence factors? How can the LD50 test...Ch. 25.3 - Prob. 2MQCh. 25.3 - Prob. 1CR
Ch. 25.4 - Prob. 1MQCh. 25.4 - Prob. 2MQCh. 25.4 - Prob. 3MQCh. 25.4 - Prob. 1CRCh. 25.5 - Prob. 1MQCh. 25.5 - Prob. 2MQCh. 25.5 - Prob. 3MQCh. 25.5 - Prob. 1CRCh. 25.6 - What key features are shared by all AB exotoxins?Ch. 25.6 - Prob. 2MQCh. 25.6 - Prob. 3MQCh. 25.6 - Prob. 1CRCh. 25.7 - Prob. 1MQCh. 25.7 - Prob. 2MQCh. 25.7 - QDistinguish between the mechanism of cytotoxins...Ch. 25.8 - What part of the Escherichia coli cell contains...Ch. 25.8 - Why is it necessary to test for endotoxin in water...Ch. 25.8 - Prob. 1CRCh. 25 - Coagulase is a virulence factor for Staphylococcus...Ch. 25 - Although mutants incapable of producing exotoxins...
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