ANAT.+PHYSIO.1-LAB.MAN. >CUSTOM<
20th Edition
ISBN: 9781264303106
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 25.1, Problem 25AYP
Summary Introduction
To analyze:
About the % daily values and its amount labeled in the food packages.
Introduction:
The % daily values for nutrients are the energy consume by us per day, it is based on 2000 kcal/day. It is important to calculate the number of nutrients managed in the total diet and this should be mentioned in the food package and the container.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 25 Solutions
ANAT.+PHYSIO.1-LAB.MAN. >CUSTOM<
Ch. 25.1 - Prob. 1AYPCh. 25.1 - Prob. 2AYPCh. 25.1 - Prob. 3AYPCh. 25.1 - Define kilocalorie. State the number of...Ch. 25.1 - List the five food groups shown in MyPlate. How is...Ch. 25.1 - What are the most common monosaccharides in the...Ch. 25.1 - Give three examples of complex carbohydrates. How...Ch. 25.1 - How does the body use glucose and other...Ch. 25.1 - Prob. 9AYPCh. 25.1 - Prob. 10AYP
Ch. 25.1 - Prob. 11AYPCh. 25.1 - How does the body use triglycerides, cholesterol....Ch. 25.1 - Describe the recommended dietary intake of lipids....Ch. 25.1 - Distinguish between essential and nonessential...Ch. 25.1 - Prob. 15AYPCh. 25.1 - Prob. 16AYPCh. 25.1 - Prob. 17AYPCh. 25.1 - Prob. 18AYPCh. 25.1 - Prob. 19AYPCh. 25.1 - Prob. 20AYPCh. 25.1 - Prob. 21AYPCh. 25.1 - Prob. 22AYPCh. 25.1 - Prob. 23AYPCh. 25.1 - Prob. 24AYPCh. 25.1 - Prob. 25AYPCh. 25.2 - Prob. 26AYPCh. 25.2 - How does the removal of hydrogen atoms from...Ch. 25.3 - Describe the four phases of glycolysis. What are...Ch. 25.3 - Prob. 29AYPCh. 25.3 - Prob. 30AYPCh. 25.3 - Prob. 31AYPCh. 25.3 - Define aerobic respiration, and list its products....Ch. 25.3 - Prob. 33AYPCh. 25.3 - Prob. 34AYPCh. 25.3 - Prob. 35AYPCh. 25.3 - Why is the total number of A produced in aerobic...Ch. 25.3 - Prob. 37AYPCh. 25.4 - Prob. 38AYPCh. 25.4 - Prob. 39AYPCh. 25.5 - Prob. 40AYPCh. 25.5 - Prob. 41AYPCh. 25.6 - Distinguish among the processes of glycogenesis,...Ch. 25.7 - Prob. 43AYPCh. 25.7 - Prob. 44AYPCh. 25.7 - When does the postabsorptive state occur?Ch. 25.7 - Prob. 46AYPCh. 25.8 - Prob. 47AYPCh. 25.8 - Prob. 48AYPCh. 25.8 - Prob. 49AYPCh. 25.8 - Prob. 50AYPCh. 25.8 - Prob. 51AYPCh. 25.9 - Prob. 52AYPCh. 25.9 - Prob. 53AYPCh. 25.9 - Prob. 54AYPCh. 25.9 - Prob. 55AYPCh. 25 - Prob. 1RACCh. 25 - Prob. 2RACCh. 25 - Prob. 3RACCh. 25 - Prob. 4RACCh. 25 - Prob. 5RACCh. 25 - Prob. 6RACCh. 25 - Prob. 7RACCh. 25 - Prob. 8RACCh. 25 - Prob. 9RACCh. 25 - Prob. 10RACCh. 25 - Prob. 11RACCh. 25 - Prob. 12RACCh. 25 - Prob. 13RACCh. 25 - Prob. 14RACCh. 25 - Prob. 15RACCh. 25 - Prob. 16RACCh. 25 - Prob. 1CTCh. 25 - Prob. 2CTCh. 25 - Prob. 3CTCh. 25 - Prob. 4CTCh. 25 - Prob. 5CTCh. 25 - Prob. 6CTCh. 25 - Prob. 7CTCh. 25 - Prob. 8CTCh. 25 - Prob. 9CT
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