ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Textbook Question
Chapter 25, Problem 35CTQ
What anatomical structures provide protection to the kidney?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 25 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 25 - Diabetes insipidus or diabetes mellitus would most...Ch. 25 - The color of urine is determined mainly by...Ch. 25 - Production of less than 50 mL/day of urine is...Ch. 25 - Peristaltic contractions occur in the ________....Ch. 25 - Somatic motor neurons must be ________ to relax...Ch. 25 - Which pan of the urinaiy system is not completely...Ch. 25 - The renal pyramids are separated from each other...Ch. 25 - The primary structure found within the medulla is...Ch. 25 - The right kidney is slightly lower because...Ch. 25 - Blood filtrate is captured in the lumen of the...
Ch. 25 - What are the names of the capillaries following...Ch. 25 - The functional unit of the kidney is called...Ch. 25 - ________ pressure must be greater on the capillary...Ch. 25 - Production of urine to modify plasma makeup is the...Ch. 25 - Systemic blood pressure must stay above 60 so that...Ch. 25 - Aquaporin channels are only found in the...Ch. 25 - Most absorption and secretion occurs in this part...Ch. 25 - The fine tuning of water recovery or disposal...Ch. 25 - Vasodilation of blood vessels to the kidneys is...Ch. 25 - When blood pressure increases, blood vessels...Ch. 25 - Which of these three paracrine chemicals cause...Ch. 25 - What hormone directly opposes the actions of...Ch. 25 - Which of these is a vasoconstrictor? nitric oxide...Ch. 25 - What signal causes the heart to secrete atrial...Ch. 25 - Which of these beverages does not have a diuretic...Ch. 25 - Progesterone can bind to receptors for which...Ch. 25 - Renin is released in response to ________....Ch. 25 - Which step in vitamin D production does the kidney...Ch. 25 - Which hormone does the kidney produce that...Ch. 25 - If there were no aquaporin channels in the...Ch. 25 - What is suggested by the presence of white blood...Ch. 25 - Both diabetes mellitus and diabetes insipidus...Ch. 25 - Why are females more likely to contract bladder...Ch. 25 - Describe how forceful urination is accomplished.Ch. 25 - What anatomical structures provide protection to...Ch. 25 - How does the renal poital system differ from the...Ch. 25 - Name the structures found in the renal hilum.Ch. 25 - Which structures make up the renal corpuscle?Ch. 25 - What are the major structures comprising the...Ch. 25 - Give the formula for net filtration pressure.Ch. 25 - Name at least five symptoms of kidney failure.Ch. 25 - Which vessels and what pail of the nephron are...Ch. 25 - Give the approximate osmolarity of fluid in the...Ch. 25 - Explain what happens to Na+ concentration in the...Ch. 25 - If you want the kidney to excrete more Na+ in the...Ch. 25 - What organs produce which hormones or enzymes in...Ch. 25 - PTH affects absorption and reabsorption of what?Ch. 25 - Why is ADH also called vasopressin?Ch. 25 - How can glucose be a diuretic?Ch. 25 - How does lack of protein in the blood cause edema?Ch. 25 - Which three electrolytes are most closely...
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