Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested. Concept introduction: The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine. Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base. The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Answer 1

Question

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Answer 2

Question

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Answer 3

Question

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Answer 4

Question

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

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Answer 5

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

Answer 6

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

Answer 7

Chapter 25, Problem 32P

Interpretation Introduction

Interpretation:

Using prostaglandin, the glaucoma drug bimatoprost is synthesized in two steps. A method for this conversion is to be suggested.

Concept introduction:

The amide can be prepared by the nucleophilic substitution of acyl chloride by the amine.

Two moles amines used with one mole of acyl chloride, because one amine molecule acts as a nucleophile and the second acts as a Brønsted base.

The carboxylic acids on reaction with thionyl chloride forms acyl chloride by replacing the hydroxyl group of the carboxylic acid with chlorine atom.

Answer 8

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Answer 9

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Answer 10

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Answer 11

Ch. 25.2 - What fatty acids are produced on hydrolysis of...Ch. 25.3 - Give the structure of the keto acyl-ACP formed...Ch. 25.4 - Prob. 3P Ch. 25.4 - Prob. 4P Ch. 25.5 - Prob. 5P Ch. 25.6 - Write the structural formula and give the IUPAC...Ch. 25.6 - Prob. 7P Ch. 25.7 - Locate the isoprene units in each of the...Ch. 25.7 - Prob. 9P Ch. 25.9 - Prob. 10P

Solution Summary: The author explains how the glaucoma drug bimatoprost is synthesized using prostaglandin.

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Chapter 25 Solutions