Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined Concept introduction: Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Question

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Answer 1

Question

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.

Conclusion

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

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Answer 2

Question

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.

Conclusion

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

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Answer 3

Question

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.

Conclusion

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

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Answer 4

Question

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.

Conclusion

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

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Answer 5

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.

Conclusion

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Answer 6

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.

Conclusion

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Answer 7

Chapter 25, Problem 1P

Interpretation Introduction

Interpretation:

Difference between the de novo synthesis and salvage-pathway synthesis of nucleotides should be determined

Concept introduction:

Purines and pyrimidines are the nucleotides, which are produced in the liver. They contain a molecule of sugar and phosphate. The location of nitrogen in both the nucleotides is different. Their pathways of synthesis are different, but they need a common phosphorylated 5-carbon monosaccharide.

Answer 8

Expert Solution & Answer

Answer to Problem 1P

De novo pathway includes the simpler substrates that are used to synthesize pyrimidines.

Salvage pathways include the preformed and recovered bases for the synthesis of purines.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Explanation of Solution

The difference between the de novo pathway and the salvage pathway is given as below:

De novo pathways	Salvage pathways
1. Simple substrates are used in the de novo pathways for the synthesis of nucleotides.	1. In the salvage pathways, bases are recovered, preformed, and reconnected to the ribose sugar.
2. It is used to synthesize all the pyrimidines. Only two precursors, aspartate, and carbamoyl phosphate, are required here.	2. It is used to synthesize the purines. Many substrates are required here for the synthesis of purines.