Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 24.2, Problem 5ELO
Understand why vaccination against smallpox has been Curtailed.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 24 Solutions
Foundations in Microbiology
Ch. 24.1 - Prob. 1ELOCh. 24.1 - Prob. 2ELOCh. 24.1 - Explain how viral structure is related to viral...Ch. 24.1 - Discuss the structures found in a typical virus.Ch. 24.1 - Differentiate among lytic infection, latent...Ch. 24.1 - Relate the importance of structure to viral...Ch. 24.1 - What accounts for the affinity of viruses for...Ch. 24.1 - What accounts for the symptoms of viral diseases?Ch. 24.1 - In what ways can people carry viruses?Ch. 24.2 - Prob. 4ELO
Ch. 24.2 - Understand why vaccination against smallpox has...Ch. 24.2 - Prob. 6ELOCh. 24.2 - What structural attributes differentiate smallpox...Ch. 24.2 - Prob. 8CYPCh. 24.2 - Prob. 9CYPCh. 24.3 - Prob. 7ELOCh. 24.3 - Prob. 8ELOCh. 24.3 - Prob. 9ELOCh. 24.3 - Prob. 10ELOCh. 24.3 - Understand the etiological agent, epidemiology,...Ch. 24.3 - Prob. 12ELOCh. 24.3 - Prob. 13ELOCh. 24.3 - Prob. 10CYPCh. 24.3 - Prob. 11CYPCh. 24.3 - Describe the ways in which HSV-1 differs from...Ch. 24.3 - Prob. 13CYPCh. 24.3 - Prob. 14CYPCh. 24.3 - Prob. 15CYPCh. 24.3 - Summarize the signs, symptoms, and epidemiology...Ch. 24.3 - What cancers are related to infection with...Ch. 24.3 - Prob. 18CYPCh. 24.4 - Contrast the major characteristics of the three...Ch. 24.4 - Understand the epidemiology, diagnosis, pathology,...Ch. 24.4 - Prob. 19CYPCh. 24.4 - Prob. 20CYPCh. 24.4 - What groups are most at risk for developing...Ch. 24.4 - What is the nature of the vaccines for hepatitis...Ch. 24.5 - Recall the structure, epidemiology, and diseases...Ch. 24.5 - Prob. 17ELOCh. 24.5 - Prob. 18ELOCh. 24.5 - Prob. 19ELOCh. 24.5 - Prob. 20ELOCh. 24.5 - Prob. 21ELOCh. 24.5 - Prob. 23CYPCh. 24.5 - Prob. 24CYPCh. 24.5 - Prob. 25CYPCh. 24.5 - What is the importance of the HPV vaccines?Ch. 24.5 - Prob. 27CYPCh. 24.5 - Prob. 28CYPCh. 24.L1 - Prob. 1MCQCh. 24.L1 - Prob. 2MCQCh. 24.L1 - Which virus is used in smallpox vaccination? a....Ch. 24.L1 - Prob. 4MCQCh. 24.L1 - Prob. 5MCQCh. 24.L1 - Prob. 6MCQCh. 24.L1 - _____ is an effective treatment for herpes simplex...Ch. 24.L1 - Which herpesvirus is most commonly associated with...Ch. 24.L1 - Prob. 9MCQCh. 24.L1 - A common sign of hepatitis is a. liver cancer b....Ch. 24.L1 - Prob. 11MCQCh. 24.L1 - Prob. 12MCQCh. 24.L1 - Parvoviruses are unique because they contain a. a...Ch. 24.L1 - Adenoviruses are the agents of a. hemorrhagic...Ch. 24.L1 - Prob. 15MCQCh. 24.L1 - Prob. 16MCQCh. 24.L1 - Prob. 17MCQCh. 24.L1 - Prob. 1CSRCh. 24.L1 - Prob. 2CSRCh. 24.L1 - Prob. 3CSRCh. 24.L1 - Prob. 1WCCh. 24.L1 - Explain the involvement of viruses in cancer and...Ch. 24.L1 - Prob. 3WCCh. 24.L1 - Develop a table for the herpesviruses that...Ch. 24.L1 - Prob. 5WCCh. 24.L1 - Prob. 6WCCh. 24.L1 - Prob. 7WCCh. 24.L2 - Prob. 1CTCh. 24.L2 - Describe several measures health care workers can...Ch. 24.L2 - Prob. 3CTCh. 24.L2 - Prob. 4CTCh. 24.L2 - a. Name two different defective viruses that...Ch. 24.L2 - Prob. 6CTCh. 24.L2 - A man wants to divorce his wife because he...Ch. 24.L2 - Weigh the following observation: High titers of...Ch. 24.L2 - Give some pros and cons of exposing children to...Ch. 24.L2 - Prob. 10CTCh. 24.L2 - What two different DNA viral infections can be...Ch. 24.L2 - Prob. 1VC
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