A transamination reaction and an oxidative deamination that shows the removal of the amino group of alanine as NH 4 + is to be stated. Concept introduction: Transamination is an important chemical reaction that involves amino acids. In transamination reaction an amino group is transferred to an α-keto acid and forms a new amino acid. The carbon atom to which amino group is attached is transformed into a new α-keto acid. An oxidative deamination is the process in which an α-amino acid degrades into ammonia and α-keto acid.

Question

Kumada Coupling: 1. m-Diisobutylbenzene below could hypothetically be synthesized by Friedel-Crafts reaction. Write out the reaction with a mechanism and give two reasons why you would NOT get the desired product. Draw the reaction (NOT a mechanism) for a Kumada coupling to produce the molecule above from m-dichlorobenzene. Calculate the theoretical yield for the reaction in question 2 using 1.5 g of p-dichlorobenzene and 3.0 mL isobutyl bromide. What signals appeared/disappeared/shifted that indicate that you have your intended product and not starting material? What other impurities are present in your product and how do you know?

Answer 1

Question

Chapter 24, Problem 24.49E

Interpretation Introduction

Interpretation:

A transamination reaction and an oxidative deamination that shows the removal of the amino group of alanine as NH4+ is to be stated.

Concept introduction:

Transamination is an important chemical reaction that involves amino acids. In transamination reaction an amino group is transferred to an α-keto acid and forms a new amino acid. The carbon atom to which amino group is attached is transformed into a new α-keto acid. An oxidative deamination is the process in which an α-amino acid degrades into ammonia and α-keto acid.

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