Chapter 24, Problem 24.31P

Interpretation Introduction

Interpretation:

The possible reactants that would be placed in boxes in the sequence of Sonogashira coupling has to be given.

Concept Introduction:

Sonogashira coupling starts with a terminal alkyne with $CuI$ and triethylamine to create a $\text{Cu-}$ alkyne complex. This undergoes reaction with vinyl or aryl iodides.

This coupling is used to create diaryl alkynes, aryl alkenyl alkynes, or dialkenyl alkynes.