Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 24, Problem 13P
Interpretation Introduction

Interpretation:

How the backtracking of ribonucleic acid (RNA) polymerase enzyme could function to enhance the fidelity of transcription should be explained.

Concept introduction:

Transcription is defined as the process of polymerization of deoxyribonucleic acid (DNA) segment, in which the DNA segment is copied into ribonucleic acid (RNA) segment.

During the transcription process, the back tracking of the enzyme ribonucleic acid polymerase is the backward movement of the enzyme from the given site. The backtracking of enzyme takes place when the enzyme finds it difficult to transcribe and also helps in correcting any error in the base pairing. Whenever any error is found, the enzyme ribonucleic acid polymerase slips into backtracking activity.

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Background Freezing isn't the only challenge in cryopreservation - thawing can be just as difficult. A microwave oven seems like a nice solution, since it deposits energy quickly and microwaves are non-ionizing radiation (they do not cause DNA mutation). However, water absorbs microwaves more effectively than ice does, meaning that the portion of an organ that has already melted will get warmer at a higher rate than the remaining ice – the opposite of what we want! - The transmission of radiation through a weakly absorbing material such as ice or water can be modeled by Beer's law, which assumes that the rate of absorption at a depth x is proportional to the local radiation intensity I(x) times an absorption coefficient, which is often written as μ or a or just µ). Noting that absorption decreases the intensity, we can write a differential equation a Solving the differential equation with the boundary condition on the surface being gives the relationship For a standard microwave oven…
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