a) The first step in the preparation of Hagemann’s ester, an aldol-like condensation between ethylacetoacetate and formaldehyde to produce a α, β-unsaturated product and the structure of the product is to be shown. b) The structure of the product obtained in the second step which is a Michael reaction between the product of the first step and ethyl acetoactate is to be given. Concept introduction: In the first step in the preparation of Hagemann’s ester involving a mixed aldol like condensation reaction, ethyl acetoacetate yields an enolate anion which attacks formaldehyde to yield an α, β-unsaturated product. In the second step α, β-unsaturated product obtained in the first step acts as a donor and ethyl acetoacetate acts as the acceptor (Michael reaction) to yield the product. To give: a) The first step in the preparation of Hagemann’s ester, an aldol-like condensation between ethylacetoacetate and formaldehyde to produce α, β-unsaturated product and the structure of the product. b) The structure of the product obtained in the second step which is a Michael reaction between the product of the first step and ethyl acetoactate.

Question

Understanding the general acid-base properties of amino acids O Proteins Imagine each of the molecules shown below was found in an aqueous solution. Can you tell whether the solution is acidic, basic, or neutral? molecule The solution is... 010 H3N-CH-C-OH CH HO CH3 O acidic O basic neutral O (unknown) H3N HO 0 O acidic O basic neutral ○ (unknown) H3N-CH-C-O CH2 CH3-CH-CH3 O acidic O basic Oneutral ○ (unknown) O= X H2N-CH-C-O CH3 CH CH3 acidic O basic O neutral ○ (unknown) ? 000

Answer 1

Question

Chapter 23.SE, Problem 71AP

Interpretation Introduction

Interpretation:

a) The first step in the preparation of Hagemann’s ester, an aldol-like condensation between ethylacetoacetate and formaldehyde to produce a α, β-unsaturated product and the structure of the product is to be shown.

b) The structure of the product obtained in the second step which is a Michael reaction between the product of the first step and ethyl acetoactate is to be given.

Concept introduction:

In the first step in the preparation of Hagemann’s ester involving a mixed aldol like condensation reaction, ethyl acetoacetate yields an enolate anion which attacks formaldehyde to yield an α, β-unsaturated product.

In the second step α, β-unsaturated product obtained in the first step acts as a donor and ethyl acetoacetate acts as the acceptor (Michael reaction) to yield the product.

To give:

a) The first step in the preparation of Hagemann’s ester, an aldol-like condensation between ethylacetoacetate and formaldehyde to produce α, β-unsaturated product and the structure of the product.

b) The structure of the product obtained in the second step which is a Michael reaction between the product of the first step and ethyl acetoactate.

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