HUMAN A+P MOD.MASTERING
2nd Edition
ISBN: 9780136919520
Author: AMERMAN
Publisher: PEARSON
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Chapter 23.7, Problem 9QC
Summary Introduction
To review:
The role played by the liver in cholesterol
Introduction:
The liver is an organ that is present only in vertebrates. The liver plays a significant role in the production of biochemical compounds. It is important for the metabolism and decomposition of the RBCs (red blood corpuscles). It also helps in the production of hormones.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
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Chapter 23 Solutions
HUMAN A+P MOD.MASTERING
Ch. 23.1 - 1. How do catabolism and anabolism differ?
Ch. 23.1 - Prob. 2QCCh. 23.1 - 3. How do endergonic and exergonic reactions...Ch. 23.1 - Why are endergonic and exergonic reactions...Ch. 23.1 - Prob. 5QCCh. 23.1 - How does ATP fuel cellular processes?Ch. 23.1 - 7. In an oxidation-reduction reaction, what...Ch. 23.1 - 8. What is electron affinity? Do electrons flow...Ch. 23.1 - What is the electromotive force?Ch. 23.2 - How do substrate-level phosphorylation and...
Ch. 23.2 - What is glycolytic catabolism? Why is it also...Ch. 23.2 - Prob. 3QCCh. 23.2 - Prob. 4QCCh. 23.2 - Prob. 5QCCh. 23.2 - 6. Why is it important to regenerate NAD+ under...Ch. 23.2 - 7. What products are generated by the citric acid...Ch. 23.2 - Prob. 8QCCh. 23.2 - What is the potential energy in the bonds of...Ch. 23.3 - Prob. 1QCCh. 23.3 - Prob. 2QCCh. 23.3 - Prob. 3QCCh. 23.3 - Prob. 4QCCh. 23.3 - Why must the body eliminate the ammonia that...Ch. 23.4 - 1. How is glucose stored in the body?
Ch. 23.4 - Prob. 2QCCh. 23.4 - Prob. 3QCCh. 23.4 - Prob. 4QCCh. 23.4 - How are nonlipids converted into fats?Ch. 23.4 - Prob. 6QCCh. 23.4 - Prob. 7QCCh. 23.5 - 1. Why does anabolism dominate in the absorptive...Ch. 23.5 - Prob. 2QCCh. 23.5 - Prob. 3QCCh. 23.5 - Prob. 4QCCh. 23.5 - Prob. 5QCCh. 23.5 - 6. How do the actions of leptin differ from those...Ch. 23.6 - Prob. 1QCCh. 23.6 - Prob. 2QCCh. 23.6 - Prob. 3QCCh. 23.6 - Prob. 4QCCh. 23.6 - Prob. 5QCCh. 23.6 - Prob. 6QCCh. 23.6 - Prob. 7QCCh. 23.6 - Prob. 8QCCh. 23.7 - Prob. 1QCCh. 23.7 - Prob. 2QCCh. 23.7 - Prob. 3QCCh. 23.7 - Prob. 4QCCh. 23.7 - Prob. 5QCCh. 23.7 - Prob. 6QCCh. 23.7 - Prob. 7QCCh. 23.7 - Why is HDL considered good cholesterol, whereas...Ch. 23.7 - Prob. 9QCCh. 23.7 - Prob. 10QCCh. 23.7 - Prob. 11QCCh. 23 - Which of the following statements is false? a....Ch. 23 - Prob. 2CYRCh. 23 - Fill in the blanks: A/an ________reaction releases...Ch. 23 - Mark the following statements as true or false. If...Ch. 23 - Prob. 5CYRCh. 23 - Place the following events of glucose catabolism...Ch. 23 - Which of the following statements is false? a....Ch. 23 - Prob. 8CYRCh. 23 - Prob. 9CYRCh. 23 - Prob. 10CYRCh. 23 - Prob. 11CYRCh. 23 - Prob. 12CYRCh. 23 - Prob. 13CYRCh. 23 - Prob. 14CYRCh. 23 - Prob. 15CYRCh. 23 - Prob. 16CYRCh. 23 - Prob. 17CYRCh. 23 - Prob. 18CYRCh. 23 - Prob. 19CYRCh. 23 - 20. Which of the following statements is false?
a....Ch. 23 - Prob. 21CYRCh. 23 - Prob. 22CYRCh. 23 - Prob. 1CYUCh. 23 - Prob. 2CYUCh. 23 - Prob. 3CYUCh. 23 - Prob. 4CYUCh. 23 - People with extremely restricted caloric intake...Ch. 23 - Prob. 1AYKACh. 23 - Prob. 2AYKACh. 23 - 3. Certain dietary supplements for weight loss...Ch. 23 - Prob. 4AYKBCh. 23 - Prob. 5AYKB
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