Chapter 23.7, Problem 23ATS

(a)

Interpretation Introduction

Interpretation:

The structure for compound 2 should be identified.

Concept Introduction:

Negishi reaction: It describes how the product obtained when organometallic compound containing $\text{Zn,}\text{Al}\text{and}\text{Zr}$ is coupled with organic electrophile in presence of palladium or nickel catalyst.

Retro synthesis: It is a technique of planning an organic synthesis by the reverse approach. In this technique, the starting materials are obtained by cleaving the target molecule into logical synthons. Synthons are precursor fragments of the target compound when it is cleaved. Depending on the stability, the synthons are classified as logical and illogical synthons. Logical synthons are highly stable precursor fragments, and illogical synthons are less stable precursor fragments of the target compound.

(b)

Interpretation Introduction

Interpretation:

The structure of gadain and the respective vinyl bromide used in the preparation of gadain should be identified.

Concept Introduction:

Negishi reaction: It describes how the product obtained when organometallic compound containing $\text{Zn,}\text{Al}\text{and}\text{Zr}$ is coupled with organic electrophile in presence of palladium or nickel catalyst.