Explanation Aspirins are prepared as an esterification reaction, where salicylic acid is treated with acetic anhydride and an acid derivate, which turns salicylic acids hydroxyl group into an ester group, aspirins are anti-inflammatory and fever reducing actions which came from t...

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

8th Edition

ISBN: 9780134015187

Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson

Publisher: PEARSON

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Question

Chapter 23.7, Problem 23.6CIAP

Interpretation Introduction

Interpretation:

The aspirin disrupting the synthesis of prostaglandins has to be explained.

Concept Introduction:

Aspirin:

Ii is commonly known as acetylsalicylic acid (ASA) which is used to treat the illness like pain and fever or inflammation, it also used in specific inflammatory conditions present in Kawasaki disease and rheumatic fever.

Structure of aspirin:

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Chapter 23.7, Problem 23.4CIAP

Chapter 23.7, Problem 23.7CIAP

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Chapter 23 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

Ch. 23.1 - Use Figure 23.1 to identify the family of lipids...Ch. 23.2 - Prob. 23.2P Ch. 23.2 - Prob. 23.3P Ch. 23.2 - Prob. 23.4KCP Ch. 23.3 - Prob. 23.1CIAP Ch. 23.3 - Prob. 23.2CIAP Ch. 23.3 - Prob. 23.3CIAP Ch. 23.3 - Prob. 23.5P Ch. 23.3 - Prob. 23.6P Ch. 23.3 - Prob. 23.7KCP

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Solution Summary: The author explains that aspirin disrupting the synthesis of prostaglandins has to be explained.

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