a) 2-Hydroxy-2-methylpentanal Interpretation: Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated. Concept introduction: Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone. To state: Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

Question

Liquid chromatography has been used to track the concentration of remdesivir (a broad-spectrum antiviral drug, structure shown at right) in COVID patients undergoing experimental treatments. Intensity The authors provide the following details regarding standard solutions preparation: HN CN HO OH NH2 Remdesivir (RDV) stock solution (5000 µg/mL) was prepared by dissolving RDV drug powder using the mixture of DMSO: MeOH (30:70 v/v). The RDV working standard solutions for calibration and quality controls were prepared using methanol in concentrations of 100, 10, 1, 0.1, 0.01 µg/mL. 1, 2.5, 5, 7.5, 10, 25, 50, 75, 100, 250, 500, 1000, and 5000 ng/mL sample solutions were prepared freshly by spiking calibration standard solutions into the blank human plasma samples for method calibration. a) What type of calibration method is being described? Why do you think the authors chose this method as opposed to another? b) Based on the details provided in part a, describe an appropriate method blank…

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 23.4, Problem 5P

Interpretation Introduction

a) 2-Hydroxy-2-methylpentanal

Interpretation:

Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated.

Concept introduction:

Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone.

To state:

Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

Interpretation Introduction

b) 5-Ethyl-4-methyl-4-hepten-3-one

Interpretation:

Whether 5-ethyl-4-methyl4-heptene-3-one is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated.

Concept introduction:

Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone.

To state:

Whether 5-Ethyl-4-methyl-4-heptene-3-one is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

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Liquid chromatography has been used to track the concentration of remdesivir (a broad-spectrum antiviral drug, structure shown at right) in COVID patients undergoing experimental treatments. Intensity The authors provide the following details regarding standard solutions preparation: HN CN HO OH NH2 Remdesivir (RDV) stock solution (5000 µg/mL) was prepared by dissolving RDV drug powder using the mixture of DMSO: MeOH (30:70 v/v). The RDV working standard solutions for calibration and quality controls were prepared using methanol in concentrations of 100, 10, 1, 0.1, 0.01 µg/mL. 1, 2.5, 5, 7.5, 10, 25, 50, 75, 100, 250, 500, 1000, and 5000 ng/mL sample solutions were prepared freshly by spiking calibration standard solutions into the blank human plasma samples for method calibration. a) What type of calibration method is being described? Why do you think the authors chose this method as opposed to another? b) Based on the details provided in part a, describe an appropriate method blank…

Recent advancements in liquid chromatography include the development of ultrahigh pressure liquid chromatography (UHPLC) and an increased use of capillary columns that had previously only been used with gas chromatography. Both of these advances have made the development of portable LC systems possible. For example, Axcend Corp. makes a portable system that uses a capillary column with an internal diameter of 150-μm-that is packed with 1.7-um stationary phase particles. In contrast, a traditional LC column has a 4.6 mm internal diameter and utilizes 5-um stationary phase particles. a) Explain one advantage that is afforded by the use of a capillary column in liquid chromatographic separation. Explain one disadvantage of capillary columns. b) Explain how the use of smaller stationary phase particles can improve the resolution of a separation. Include any relevant equations that support your explanation. c) A scientist at Rowan University is using the Axcend LC to conduct analyses of F…

This paper describes the use of fullerene molecules, also known as buckyballs, as a stationary phase for liquid chromatography. The performance of the fullerene-modified stationary phase (FMS) is compared to that of a more common C18 stationary phase and to two other carbon-based stationary phases, PGC and COZ. A. 10A OM B. - Figure 1. Idealized drawing of the cross-section of a pore inside a silica particle, showing the relative densities of aminopropylsilyl (red/green) and fullerene (blue) groups: (A) full cross- section; (B) detailed view of covalent bonding of fullerene to the silica surface. Surface densities of silyl and fullerene groups were inferred from elemental composition results obtained at each stage of the synthesis (see Table 1). Absorbance (mAU, 220 nm) 700 600 500 400 300 200 100 a. Define selectivity, a, with words and an equation. b. Explain how the choice of stationary phase affects selectivity. c. Calculate the resolution of the nitrobenzene and toluene peaks in…

Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 23.4, Problem 5P

Interpretation Introduction

a) 2-Hydroxy-2-methylpentanal

Interpretation:

Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated.

Concept introduction:

Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone.

To state:

Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

Interpretation Introduction

b) 5-Ethyl-4-methyl-4-hepten-3-one

Interpretation:

Whether 5-ethyl-4-methyl4-heptene-3-one is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated.

Concept introduction:

Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone.

To state:

Whether 5-Ethyl-4-methyl-4-heptene-3-one is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

Expert Solution & Answer

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Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 23.4, Problem 5P

Interpretation Introduction

a) 2-Hydroxy-2-methylpentanal

Interpretation:

Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated.

Concept introduction:

Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone.

To state:

Whether 2-hydroxy-2-methylpentanal is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

Interpretation Introduction

b) 5-Ethyl-4-methyl-4-hepten-3-one

Interpretation:

Whether 5-ethyl-4-methyl4-heptene-3-one is an aldol condensation product or not is to be stated. The aldehyde or ketone precursor from which it can be prepared also is to be stated.

Concept introduction:

Aldehydes and ketones with α-hydrogen undergo a base catalyzed carbonyl condensation reaction in aldol condensation. In this reaction two molecules of the reactant combine by forming a bond between α-carbon of one molecule and the carbonyl carbon of the second molecule. The product obtained is a β-hydroxyaldehyde or ketone.

To state:

Whether 5-Ethyl-4-methyl-4-heptene-3-one is an aldol condensation product or not. Further to state the aldehyde or ketone precursor from which it can be prepared.

Expert Solution & Answer

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Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 23.4, Problem 5P

Interpretation Introduction