Biochemistry
9th Edition
ISBN: 9781305961135
Author: Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher: Cengage Learning
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Chapter 23, Problem 7RE
Interpretation Introduction
Interpretation:
The usefulness of feedback control mechanism to organisms in long biosynthetic pathways.
Concept Introduction:
Feedback inhibition refers to the inhibition of enzymatic activity by the final product formed at the end of sequence of reactions. Without this mechanism, product is produced more than what is required.
Organisms spend energy in each step of biosynthesis of amino acids or
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Chapter 23 Solutions
Biochemistry
Ch. 23 - RECALL What kinds of organisms can fix nitrogen?...Ch. 23 - RECALL How is nitrogen fixed (converted from...Ch. 23 - Prob. 3RECh. 23 - Prob. 4RECh. 23 - Prob. 5RECh. 23 - Prob. 6RECh. 23 - Prob. 7RECh. 23 - REFLECT AND APPLY Metabolic cycles are rather...Ch. 23 - RECALL What is the relationship between...Ch. 23 - Prob. 10RE
Ch. 23 - Prob. 11RECh. 23 - Prob. 12RECh. 23 - Prob. 13RECh. 23 - Prob. 14RECh. 23 - Prob. 15RECh. 23 - Prob. 16RECh. 23 - Prob. 17RECh. 23 - Prob. 18RECh. 23 - REFLECT AND APPLY Sulfanilamide and related sulfa...Ch. 23 - Prob. 20RECh. 23 - Prob. 21RECh. 23 - Prob. 22RECh. 23 - Prob. 23RECh. 23 - Prob. 24RECh. 23 - RECALL Describe citrulline and ornithine based on...Ch. 23 - Prob. 26RECh. 23 - Prob. 27RECh. 23 - Prob. 28RECh. 23 - Prob. 29RECh. 23 - Prob. 30RECh. 23 - Prob. 31RECh. 23 - Prob. 32RECh. 23 - Prob. 33RECh. 23 - Prob. 34RECh. 23 - Prob. 35RECh. 23 - Prob. 36RECh. 23 - REFLECT AND APPLY Why is it better, when running a...Ch. 23 - REFLECT AND APPLY Argue logically that the urea...Ch. 23 - BIOCHEMICAL CONNECTIONS How is the importance of...Ch. 23 - Prob. 40RECh. 23 - RECALL What is the structural difference between...Ch. 23 - Prob. 42RECh. 23 - RECALL Does the conversion of IMP to GMP use or...Ch. 23 - RECALL Discuss the role of feedback inhibition in...Ch. 23 - RECALL How many high-energy phosphate bonds must...Ch. 23 - REFLECT AND APPLY Why do most mammals, other than...Ch. 23 - Prob. 47RECh. 23 - RECALL Compare the fates of the products of purine...Ch. 23 - Prob. 49RECh. 23 - Prob. 50RECh. 23 - REFLECT AND APPLY Chemotherapy patients receiving...
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- REFLECT AND APPLY Outline the methods you would use to pro- duce human growth hormone (a substance used in the treatment of dwarfism) in bacteria.arrow_forwardREFLECT AND APPLY Comment on the energetics of protein folding in light of the information in this chapter.arrow_forwardREFLECT AND APPLY Noncompetitive inhibition is a limiting case in which the effect of binding inhibitor has no effect on the affinity for the substrate and vice versa. Suggest what a LineweaverBurk plot would look like for an inhibitor that had a reaction scheme similar to that on page 159 (noncompetitive inhibition reaction), but where binding inhibitor lowered the affinity of EI for the substrate.arrow_forward
- REFLECT AND APPLY Why can we say that having a pure non- competitive inhibitor present is similar to just having less enzyme present?arrow_forwardREFLECT AND APPLY List two classes of compounds derived from arachidonic acid. Suggest some reasons for the amount of biomedical research devoted to these compounds.arrow_forwardREFLECT AND APPLY The enzyme D-amino acid oxidase has a very high turnover number because the D-amino acids are potentially toxic. The KM for the enzyme is in the range of 1 to 2 mM for the aromatic amino acids and in the range of 15 to 20 mM for such amino acids as serine, alanine, and the acidic amino acids. Which of these amino acids are the preferred substrates for the enzyme?arrow_forward
- REFLECT AND APPLY Albert Szent-Gyorgi, a pioneer in early photosynthesis research, stated, What drives life is a little electric current, kept up by the sunshine. What did he mean by this?arrow_forwardREFLECT AND APPLY How can different time scales for response be achieved in control mechanisms?arrow_forwardREFLECT AND APPLY When we compare the binding of I and of S to the enzyme in a mixed noncompetitive inhibitor, we assumed that the binding of I decreased the affinity of the enzyme for S. What would happen if the opposite were true?arrow_forward
- REFLECT AND APPLY Sulfanilamide and related sulfa drugs were widely used to treat diseases of bacterial origin before penicillin and more advanced drugs were readily available. The inhibitory effect of sulfanilamide on bacterial growth can be reversed by p-aminobenzoate. Suggest a mode of action for sulfanilamide.arrow_forwardREFLECT AND APPLY Suggest a reason why heating a solution containing an enzyme markedly decreases its activity. Why is the decrease of activity frequently much less when the solution contains high concentrations of the substrate?arrow_forwardREFLECT AND APPLY A model is proposed to explain the reaction catalyzed by an enzyme. Experimentally obtained rate data fit the model to within experimental error. Do these findings prove the model?arrow_forward
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