EBK HUMAN ANATOMY
9th Edition
ISBN: 9780135241752
Author: Marieb
Publisher: PEARSON CO
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Chapter 23, Problem 4CRCAQ
Eva, a middle-aged attorney, complains of a burning pain in the� pit of her stomach," usually beginning about 2 hours after eating and lessening after she drinks a glass of milk. ‘When asked to indicate the site of pain, she points to her epigastric region. When her GI tract is examined by endoscopy, a gastric ulcer is visualized. What are the possible consequences if the ulcer goes untreated?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 23 Solutions
EBK HUMAN ANATOMY
Ch. 23 - Where in the alimentary canal does propulsion...Ch. 23 - Differentiate the abdominal cavity from the...Ch. 23 - Identify all the mesenteries that connect to each...Ch. 23 - Prob. 4CYUCh. 23 - Name the three sublayers of the mucosa. Which...Ch. 23 - Name the tissue layer of the alimentary canal that...Ch. 23 - Contrast smooth muscle to skeletal muscle, noting...Ch. 23 - What type of epithelium forms the mucosa lining...Ch. 23 - Name the three major salivary glands. What...Ch. 23 - Prob. 10CYU
Ch. 23 - How does the epithelial lining change from the...Ch. 23 - Describe the location of the stomach in reference...Ch. 23 - What do chief cells produce? What do parietal...Ch. 23 - Prob. 14CYUCh. 23 - Name all the parts of the large intestine,...Ch. 23 - Name the structures within the villus that receive...Ch. 23 - Name the vessels and ducts that pass through the...Ch. 23 - Trace the path of blood drained from the digestive...Ch. 23 - Prob. 19CYUCh. 23 - Why is it so important to wash your hands after...Ch. 23 - Which embryonic germ layer forms the epithelium of...Ch. 23 - What blood vessel supplies the structures derived...Ch. 23 - Which of the following organs is secondarily...Ch. 23 - Prob. 2RQCh. 23 - For each organ in the left-hand column, select the...Ch. 23 - Match each of the mesenteries in the key with the...Ch. 23 - Prob. 5RQCh. 23 - Prob. 6RQCh. 23 - Which of the following correctly describe the flow...Ch. 23 - The exocrine glands in the pancreas are (a) simple...Ch. 23 - Prob. 9RQCh. 23 - Which one of the following features is shared by...Ch. 23 - Prob. 11RQCh. 23 - Prob. 12RQCh. 23 - Protein digestion begins (a) in the mouth by...Ch. 23 - The calcified connective tissue that attaches the...Ch. 23 - Prob. 15RQCh. 23 - Prob. 16RQCh. 23 - The salivary gland that contains only serous cells...Ch. 23 - Use the key below to indicate the blood vessel...Ch. 23 - Make a simple drawing of the organs of the...Ch. 23 - Name the layers of the wall of the alimentary...Ch. 23 - (a) Write the dental formulas for both the...Ch. 23 - Bianca went on a trip to the Bahamas during spring...Ch. 23 - (a) Make a rough sketch of the Visceral surface of...Ch. 23 - Name four structural features that increase the...Ch. 23 - (a) List the three major vessels of the portal...Ch. 23 - Of the three major salivary glands, which is the...Ch. 23 - Trace the entire duct systems of the liver and...Ch. 23 - Prob. 28RQCh. 23 - Prob. 29RQCh. 23 - Prob. 30RQCh. 23 - Prob. 31RQCh. 23 - This chapter describes schemes that divided the...Ch. 23 - A 21-year-old man with severe appendicitis did not...Ch. 23 - Duncan, an inquisitive 8-year-old, saw his...Ch. 23 - Eva, a middle-aged attorney, complains of a...Ch. 23 - Prob. 5CRCAQCh. 23 - The janitor who cleaned the anatomy lab had a...Ch. 23 - Explain why cancer chemotherapies that stop the...Ch. 23 - From what embryonic layer (ectoderm, mesoderm, or...Ch. 23 - Name the three major salivary glands. What...Ch. 23 - Rebound tenderness in the lower right quadrant of...
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