EBK HUMAN ANATOMY
9th Edition
ISBN: 9780135241752
Author: Marieb
Publisher: PEARSON CO
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 23, Problem 2CRCAQ
A 21-year-old man with severe appendicitis did not seek treatment in time and died a week after his abdominal pain and fever began. Explain why appendicitis can quickly lead to death.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 23 Solutions
EBK HUMAN ANATOMY
Ch. 23 - Where in the alimentary canal does propulsion...Ch. 23 - Differentiate the abdominal cavity from the...Ch. 23 - Identify all the mesenteries that connect to each...Ch. 23 - Prob. 4CYUCh. 23 - Name the three sublayers of the mucosa. Which...Ch. 23 - Name the tissue layer of the alimentary canal that...Ch. 23 - Contrast smooth muscle to skeletal muscle, noting...Ch. 23 - What type of epithelium forms the mucosa lining...Ch. 23 - Name the three major salivary glands. What...Ch. 23 - Prob. 10CYU
Ch. 23 - How does the epithelial lining change from the...Ch. 23 - Describe the location of the stomach in reference...Ch. 23 - What do chief cells produce? What do parietal...Ch. 23 - Prob. 14CYUCh. 23 - Name all the parts of the large intestine,...Ch. 23 - Name the structures within the villus that receive...Ch. 23 - Name the vessels and ducts that pass through the...Ch. 23 - Trace the path of blood drained from the digestive...Ch. 23 - Prob. 19CYUCh. 23 - Why is it so important to wash your hands after...Ch. 23 - Which embryonic germ layer forms the epithelium of...Ch. 23 - What blood vessel supplies the structures derived...Ch. 23 - Which of the following organs is secondarily...Ch. 23 - Prob. 2RQCh. 23 - For each organ in the left-hand column, select the...Ch. 23 - Match each of the mesenteries in the key with the...Ch. 23 - Prob. 5RQCh. 23 - Prob. 6RQCh. 23 - Which of the following correctly describe the flow...Ch. 23 - The exocrine glands in the pancreas are (a) simple...Ch. 23 - Prob. 9RQCh. 23 - Which one of the following features is shared by...Ch. 23 - Prob. 11RQCh. 23 - Prob. 12RQCh. 23 - Protein digestion begins (a) in the mouth by...Ch. 23 - The calcified connective tissue that attaches the...Ch. 23 - Prob. 15RQCh. 23 - Prob. 16RQCh. 23 - The salivary gland that contains only serous cells...Ch. 23 - Use the key below to indicate the blood vessel...Ch. 23 - Make a simple drawing of the organs of the...Ch. 23 - Name the layers of the wall of the alimentary...Ch. 23 - (a) Write the dental formulas for both the...Ch. 23 - Bianca went on a trip to the Bahamas during spring...Ch. 23 - (a) Make a rough sketch of the Visceral surface of...Ch. 23 - Name four structural features that increase the...Ch. 23 - (a) List the three major vessels of the portal...Ch. 23 - Of the three major salivary glands, which is the...Ch. 23 - Trace the entire duct systems of the liver and...Ch. 23 - Prob. 28RQCh. 23 - Prob. 29RQCh. 23 - Prob. 30RQCh. 23 - Prob. 31RQCh. 23 - This chapter describes schemes that divided the...Ch. 23 - A 21-year-old man with severe appendicitis did not...Ch. 23 - Duncan, an inquisitive 8-year-old, saw his...Ch. 23 - Eva, a middle-aged attorney, complains of a...Ch. 23 - Prob. 5CRCAQCh. 23 - The janitor who cleaned the anatomy lab had a...Ch. 23 - Explain why cancer chemotherapies that stop the...Ch. 23 - From what embryonic layer (ectoderm, mesoderm, or...Ch. 23 - Name the three major salivary glands. What...Ch. 23 - Rebound tenderness in the lower right quadrant of...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.arrow_forwardWhich single food item contained you ate for the 3 days with the most sodium?arrow_forwardSelect a diet and choose one site that provides credible information. Explain why the source itself and/or the information on the site is credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The credible website name and link What makes the credible website credible?arrow_forward
- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
- The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?arrow_forwardView History Bookmarks Window Help Quarter cements ents ons (17) YouTube Which amino acids would you expect to find marked on the alpha helix? canvas.ucsc.edu ucsc Complaint and Grievance Process - Academic Personnel pach orations | | | | | | | | | | | | | | | | 000000 000000000 | | | | | | | | | | | | | | | | | | | | | | 00000000 scope vious De 48 12.415 KATPM FEB 3 F1 F2 80 F3 a F4 F5 2 # 3 $ 85 % tv N A の Mon Feb 3 10:24 PM Lipid bilayer Submit Assignment Next > ZOOM < Å DII 8 བ བ F6 16 F7 F8 F9 F10 34 F11 F12 & * ( 6 7 8 9 0 + 11 WERTY U { 0 } P deletearrow_forwardDifferent species or organisms research for ecologyarrow_forward
- What is the result of the following gram stain: positive ○ capsulated ○ acid-fast ○ negativearrow_forwardWhat type of stain is the image below: capsule stain endospore stain gram stain negative stain ASM MicrobeLibrary.org Keplingerarrow_forwardWhat is the result of the acid-fast stain below: Stock Images by Getty Images by Getty Images by Getty Images by Getty Image Getty Images St Soy Getty Images by Getty Images by Getty Images Joy Getty encapsulated O endosporulating negative ○ positivearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
- Understanding Health Insurance: A Guide to Billin...Health & NutritionISBN:9781337679480Author:GREENPublisher:Cengage
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Understanding Health Insurance: A Guide to Billin...
Health & Nutrition
ISBN:9781337679480
Author:GREEN
Publisher:Cengage
What is food insecurity?; Author: RWJBarnabas Health;https://www.youtube.com/watch?v=fXXiuLgiL18;License: Standard youtube license