Lungs are respiratory organs located in the thoracic cavity. Lungs consist of lobes. Right lung consists of three lobes, whereas left lung consists of two lobes. Lobes are further divided into bronchopulmonary segments. The right and left lobes of the lungs attach to the right and left bronchus respectively. The bronchus is further divided into many bronchioles that consist of alveoli. A bunch of alveoli present on a single respiratory bronchiole is termed as a lobule.

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The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2

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Chapter 23, Problem 2DYB

Summary Introduction

Introduction:

Lungs are respiratory organs located in the thoracic cavity. Lungs consist of lobes. Right lung consists of three lobes, whereas left lung consists of two lobes. Lobes are further divided into bronchopulmonary segments. The right and left lobes of the lungs attach to the right and left bronchus respectively. The bronchus is further divided into many bronchioles that consist of alveoli. A bunch of alveoli present on a single respiratory bronchiole is termed as a lobule.

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The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2

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