Chapter 23, Problem 25P

Interpretation Introduction

Interpretation:

The missing reagents and the structure of compound A in the synthesis of tamoxifen are to be determined.

Concept introduction:

The grignard reagent is prepared by the reaction of alkyl or aryl bromide with magnesium metal in the presence of ether.

The reaction of the grignard reagent with an aldehyde/ketone followed by hydrolysis yields alcohol.

Oxidation reaction involves an increase in the $\text{C}-\text{X}$ bonds (where X usually is oxygen or a halogen atom) or decrease in the $\text{C}-\text{H}$ bonds and vice versa for the reduction reaction.