ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Textbook Question
Chapter 23, Problem 20RQ
Where does the majority of chemical digestion in the stomach occur?
- fundus and body
- cardia and fundus
- body and pyloins
- body
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 23 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 23 - By clicking on this link...Ch. 23 - Visit this site...Ch. 23 - Watch this animation...Ch. 23 - Watch this animation...Ch. 23 - Watch this animation...Ch. 23 - By watching this animation...Ch. 23 - Watch this video...Ch. 23 - Which of these organs is not considered an...Ch. 23 - Which of the following organs is supported by a...Ch. 23 - Which of the following membranes covers the...
Ch. 23 - Which of these processes occurs in the mouth?...Ch. 23 - Which of these processes occurs throughout most of...Ch. 23 - Which of the following stimuli activates sensors...Ch. 23 - Which of these statements about reflexes in the GI...Ch. 23 - Which of these ingredients in saliva is...Ch. 23 - Which of these statements about the pharynx is...Ch. 23 - Which structure is located where the esophagus...Ch. 23 - Which phase of deglutition involves contraction of...Ch. 23 - Which of these cells secrete hormones? parietal...Ch. 23 - Where does the majority of chemical digestion in...Ch. 23 - During gastric emptying, chyme is released into...Ch. 23 - Parietal cells secrete ________. gastrin...Ch. 23 - In which pail of the alimentary canal does most...Ch. 23 - Which of these is most associated with villi?...Ch. 23 - What is the roLe of the small intestines MALT?...Ch. 23 - Which part of the large intestine attaches to the...Ch. 23 - Which of these statements about bile is true?...Ch. 23 - Pancreatic juice ________. deactivates bile. is...Ch. 23 - Where does the chemical digestion of starch begin?...Ch. 23 - Which of these is involved in the chemical...Ch. 23 - Where are most fat-digesting enzymes produced?...Ch. 23 - Which of these nutrients is absorbed mainly in the...Ch. 23 - Explain how the enteric nervous system supports...Ch. 23 - What layer of the alimentary canal tissue is...Ch. 23 - Offer a theory to explain why segmentation occurs...Ch. 23 - It has been several hours since you last ate....Ch. 23 - The composition of saliva varies from gland to...Ch. 23 - During a hockey game, the puck hits a player in...Ch. 23 - What prevents swallowed food from entering the...Ch. 23 - Explain the mechanism responsible for...Ch. 23 - Describe the three processes involved in the...Ch. 23 - Explain how the stomach is protected from self...Ch. 23 - Describe unique anatomical features that enable...Ch. 23 - Explain how nutrients absorbed in the small...Ch. 23 - Why is it important that chyme from the stomach is...Ch. 23 - Describe three of the differences between the...Ch. 23 - Why does the pancreas secrete some enzymes in...Ch. 23 - Describe the location of hepatocytes in the liver...Ch. 23 - Explain the role of bile salts and lecithin in the...Ch. 23 - How is vitamin B12 absorbed?
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