The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others. Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

Question

Want to see the full answer?

Answer 1

Question

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Biology Question

✓ Details Draw a protein that is embedded in a membrane (a transmembrane protein), label the lipid bilayer and the protein. Identify the areas of the lipid bilayer that are hydrophobic and hydrophilic. Draw a membrane with two transporters: a proton pump transporter that uses ATP to generate a proton gradient, and a second transporter that moves glucose by secondary active transport (cartoon-like is ok). It will be important to show protons moving in the correct direction, and that the transporter that is powered by secondary active transport is logically related to the proton pump.

drawing chemical structure of ATP. please draw in and label whats asked. Thank you.

Answer 2

Question

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Answer 6

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

Answer 7

Chapter 23, Problem 1CS

a.

Summary Introduction

To determine: The ways by which a dominant mutation originate a developmental malformation in some cases while nonpenetrant in others.

Introduction: In humans, HOXD genes are essential in limb development. An analysis of several families with malformations known as rocker bottom foot or claw foot revealed that rocker bottom foot has an autosomal dominant form of inheritance with variable expressivity and incomplete penetrance.

Answer 8

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Answer 9

(b)

Summary Introduction

To determine: The ways by which variable expressivity leads in two different disorders from the same mutation.

Introduction: The penetrance of the mutation is defined as the percentage of individuals that show some degree of expression of the mutant genotype. By contrast, the expressivity defines the range of expression of the mutant genotype.

Answer 10

Expert Solution & Answer

Answer 11

Expert Solution & Answer

Answer 12

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 13

Ch. 23 - Suppose you initiate a screen for maternal-effect...Ch. 23 - Prob. 2NST Ch. 23 - Prob. 1CS Ch. 23 - Prob. 2CS Ch. 23 - Prob. 1PDQ Ch. 23 - Prob. 2PDQ Ch. 23 - Prob. 3PDQ Ch. 23 - Nuclei from almost any source may be injected into...Ch. 23 - Distinguish between the syncytial blastoderm stage...Ch. 23 - Prob. 6PDQ

Solution Summary: The author analyzes how a dominant mutation causes developmental malformations in some cases, while nonpenetrant in others, because it's located in the homeodomain recognition sequence.

Videos

Want to see the full answer?

Chapter 23 Solutions