The way in which central tolerance differ from peripheral tolerance. Concept introduction: The process of deletion of T lymphocytes in the thymus that is self-reactive is known as central tolerance. The peripheral tolerance is mediated by the regulatory T cells that suppress CD+ T cells. The apoptosis and negative selection occur in primary lymphoid organs.

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Chapter 22.5, Problem 20WDL

Summary Introduction

To determine:

The way in which central tolerance differ from peripheral tolerance.

Concept introduction:

The process of deletion of T lymphocytes in the thymus that is self-reactive is known as central tolerance. The peripheral tolerance is mediated by the regulatory T cells that suppress CD+ T cells. The apoptosis and negative selection occur in primary lymphoid organs.

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