Anatomy & Physiology
3rd Edition
ISBN: 9781259398629
Author: McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher: Mcgraw Hill Education,
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Chapter 22.6, Problem 31LO
Summary Introduction
To compare: The activation of B-lymphocytes and T-lymphocytes.
Concept introduction: Lymphocytes are the primary cells involved in the immune response (one among the white blood cells) that are produced in the bone marrow. There are two groups of lymphocytes namely B-lymphocytes and T-lymphocytes.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 22 Solutions
Anatomy & Physiology
Ch. 22.1 - Prob. 1LOCh. 22.1 - Prob. 2LOCh. 22.1 - Which pathogen must enter a cell to replicate?...Ch. 22.2 - Prob. 3LOCh. 22.2 - Prob. 2WDLCh. 22.2 - Prob. 4LOCh. 22.2 - Prob. 5LOCh. 22.2 - What is the definition of a cytokine? How are...Ch. 22.2 - Prob. 6LOCh. 22.2 - Prob. 4WDL
Ch. 22.3 - Prob. 7LOCh. 22.3 - Prob. 5WDLCh. 22.3 - LEARNING OBJECTIVE
8. Describe the cells that...Ch. 22.3 - Prob. 6WDLCh. 22.3 - How do NK cells accomplish the task of eliminating...Ch. 22.3 - Prob. 9LOCh. 22.3 - Prob. 10LOCh. 22.3 - Prob. 11LOCh. 22.3 - Prob. 8WDLCh. 22.3 - Prob. 12LOCh. 22.3 - Prob. 13LOCh. 22.3 - Prob. 14LOCh. 22.3 - Prob. 1WDTCh. 22.3 - Prob. 9WDLCh. 22.3 - Prob. 10WDLCh. 22.3 - Prob. 15LOCh. 22.3 - Prob. 16LOCh. 22.3 - Prob. 11WDLCh. 22.3 - Prob. 12WDLCh. 22.4 - Prob. 17LOCh. 22.4 - Prob. 18LOCh. 22.4 - Prob. 19LOCh. 22.4 - Prob. 13WDLCh. 22.4 - What distinguishes a hapten from an antigen?Ch. 22.4 - Prob. 20LOCh. 22.4 - Prob. 2WDTCh. 22.4 - Prob. 15WDLCh. 22.4 - Prob. 21LOCh. 22.4 - LEARNING OBJECTIVE
22. Describe antigen-presenting...Ch. 22.4 - LEARNING OBJECTIVE
23. Explain the process of...Ch. 22.4 - Prob. 24LOCh. 22.4 - Which type of MHC class molecules is found on all...Ch. 22.4 - Prob. 25LOCh. 22.4 - Prob. 17WDLCh. 22.5 - Prob. 26LOCh. 22.5 - Prob. 18WDLCh. 22.5 - Prob. 27LOCh. 22.5 - Prob. 19WDLCh. 22.5 - Prob. 28LOCh. 22.5 - LEARNING OBJECTIVE
29. Describe the formation and...Ch. 22.5 - Prob. 20WDLCh. 22.6 - LEARNING OBJECTIVE
30. Describe how both helper...Ch. 22.6 - Prob. 21WDLCh. 22.6 - How do cytokines released by helper T-lymphocytes...Ch. 22.6 - LEARNING OBJECTIVE
31. Compare the activation of...Ch. 22.6 - Prob. 23WDLCh. 22.6 - Prob. 24WDLCh. 22.6 - Prob. 32LOCh. 22.6 - Prob. 25WDLCh. 22.7 - Prob. 33LOCh. 22.7 - Prob. 34LOCh. 22.7 - Prob. 35LOCh. 22.7 - Prob. 3WDTCh. 22.7 - Prob. 26WDLCh. 22.7 - Prob. 27WDLCh. 22.7 - Prob. 36LOCh. 22.7 - Prob. 37LOCh. 22.7 - Prob. 28WDLCh. 22.8 - Prob. 38LOCh. 22.8 - Prob. 29WDLCh. 22.8 - Prob. 39LOCh. 22.8 - What are the six major functions of antibodies?...Ch. 22.8 - Prob. 40LOCh. 22.8 - Which subclass of antibodies is most prevalent?...Ch. 22.9 - Prob. 41LOCh. 22.9 - Prob. 32WDLCh. 22.9 - Prob. 42LOCh. 22.9 - Prob. 33WDLCh. 22.9 - Prob. 43LOCh. 22.9 - LEARNING OBJECTIVE
44. Describe how both active...Ch. 22.9 - Prob. 34WDLCh. 22 - Prob. 1DYBCh. 22 - _____ 2. This cell releases cytokines to activate...Ch. 22 - _____ 3. This cell is activated by binding...Ch. 22 - _____ 4. These two cells destroy an infected cell...Ch. 22 - _____ 5. All of the following are functions of...Ch. 22 - Prob. 6DYBCh. 22 - _____ 7. During which process does additional...Ch. 22 - _____ 8. This chemical is released by...Ch. 22 - _____ 9. The correct sequence of the major events...Ch. 22 - Prob. 10DYBCh. 22 - Compare the general characteristics of innate...Ch. 22 - Define the inflammatory response, and explain its...Ch. 22 - Describe an antigen.Ch. 22 - Describe class I and class II MHC molecules, and...Ch. 22 - Prob. 15DYBCh. 22 - Prob. 16DYBCh. 22 - Explain the general function of cytotoxic...Ch. 22 - Describe both the function of antibodies and...Ch. 22 - There are two branches of adaptive immunity:...Ch. 22 - Prob. 20DYBCh. 22 - Prob. 1CALCh. 22 - Prob. 2CALCh. 22 - Prob. 3CALCh. 22 - Prob. 4CALCh. 22 - Prob. 5CALCh. 22 - Prob. 1CSLCh. 22 - Prob. 2CSLCh. 22 - Prob. 3CSL
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