The reason why during glycolysis, glucose-6-phosphate isomerizes to fructcose-6-phosphate before the cleavage reaction with aldolase takes place has to be explained. Concept introduction: Enzyme is a protein that is a biological catalyst. The reactant in a reaction catalyzed by the enzyme is called substrate. In the enzyme, a pocket like cleft is present called active site where it binds the substrate. Some amino acid chains in the enzyme act as base, acid and nucleophilic catalyst. Many of the enzymes contain metal ions at the active site which acts as catalyst. Acid Catalyst helps in increasing the rate of a particular reaction by the donation of a proton to substrate. Base Catalyst helps in increasing the rate of a particular reaction by the removal of a proton to substrate. Nucleophilic catalysis helps in increasing the rate of a particular reaction by the formation of a covalent bond with substrate Glycolysis: A series of reactions where glucose is converted to two pyruvate molecules in the presence of enzymes catalysis.

Question

1. Refer to the compounds below to answer the following questions: CO₂Et 0 C. H O O₂N-CH2-C-CH3 0 OEt || 111 A. Indicate all the acidic hydrogens in Compounds I through IV. IV B. Indicate which hydrogens in Compound II are the most acidic. Explain your answer C. Choose the most acidic compound from Compounds I - IV. Explain your choice.

Answer 1

Question

Chapter 22.13, Problem 27P

Interpretation Introduction

Interpretation: The reason why during glycolysis, glucose-6-phosphate isomerizes to fructcose-6-phosphate before the cleavage reaction with aldolase takes place has to be explained.

Concept introduction:

Enzyme is a protein that is a biological catalyst. The reactant in a reaction catalyzed by the enzyme is called substrate. In the enzyme, a pocket like cleft is present called active site where it binds the substrate.

Some amino acid chains in the enzyme act as base, acid and nucleophilic catalyst. Many of the enzymes contain metal ions at the active site which acts as catalyst.

Acid Catalyst helps in increasing the rate of a particular reaction by the donation of a proton to substrate.

Base Catalyst helps in increasing the rate of a particular reaction by the removal of a proton to substrate.

Nucleophilic catalysis helps in increasing the rate of a particular reaction by the formation of a covalent bond with substrate

Glycolysis: A series of reactions where glucose is converted to two pyruvate molecules in the presence of enzymes catalysis.

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