ORGANIC CHEMISTRY LL BUNDLE
ORGANIC CHEMISTRY LL BUNDLE
4th Edition
ISBN: 9781119761112
Author: Klein
Publisher: WILEY
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Chapter 22, Problem 67PP
Interpretation Introduction

Interpretation: For a given reaction, the expected product has to be found via reductive amination

Concept Introduction:

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride.  It reduces the carbonyl group into amine group in a rapid way.  So, it is called as reductive amination reactions.  Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

ORGANIC CHEMISTRY LL BUNDLE, Chapter 22, Problem 67PP , additional homework tip  1

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

ORGANIC CHEMISTRY LL BUNDLE, Chapter 22, Problem 67PP , additional homework tip  2

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

ORGANIC CHEMISTRY LL BUNDLE, Chapter 22, Problem 67PP , additional homework tip  3

To find: Plan the expected product via reductive amination using the given starting material

Draw the structures of the starting material and decide the reaction conditions

ORGANIC CHEMISTRY LL BUNDLE, Chapter 22, Problem 67PP , additional homework tip  4

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Chapter 22 Solutions

ORGANIC CHEMISTRY LL BUNDLE

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