Chapter 22, Problem 59P

Interpretation Introduction

Interpretation: The active site of the phosphoenolpyruvate kinase that interact with ${\text{=CH}}_{\text{2}}$ and its substrate is to be described.

Concept introduction: The enzyme consists of a substrate-binding site (active site) whose overall geometry should match with the substrate for successful catalysis of a biochemical reaction. Moreover, the type of interactions between the substrate and the enzyme surface is also necessary. This can be illustrated with an example of enzyme pyruvate kinase and the substrate phosphoenolpyruvate.