The reasons that the women of childbearing age should begin taking precautions to prevent birth defects, even before a woman is pregnant. Introduction: Birth defects are any complication that occurs during pregnancy and results in a baby born with some developmental anomaly. They cannot always be prevented but care before pregnancy called prenatal care can bring down the chances of occurrence of birth defects.

Question

According to a recent study, 1 out of 50,000 people will be diagnosed with cystic fibrosis. Cystic fibrosis can be caused by a mutant form of the CFTR gene (dominant gene symbol is F and mutant is f). A. Using the rate of incidence above, what is the frequency of carriers of the cystic fibrosis allele for CFTR in the US? (3 pts) B. In a clinical study, 400 people from the population mentioned in (A.) were genotyped for BRCA1 Listed below are the results. Are these results in Hardy- Weinberg equilibrium? Use Chi Square to show whether or not they are. (3 pts) BRCA1 genotype # of women 390 BB Bb bb 10 0 12pt Paragraph L BIUAV V T² v V

Answer 1

Question

Chapter 22, Problem 3TC

Summary Introduction

To review:

The reasons that the women of childbearing age should begin taking precautions to prevent birth defects, even before a woman is pregnant.

Introduction:

Birth defects are any complication that occurs during pregnancy and results in a baby born with some developmental anomaly. They cannot always be prevented but care before pregnancy called prenatal care can bring down the chances of occurrence of birth defects.

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According to a recent study, 1 out of 50,000 people will be diagnosed with cystic fibrosis. Cystic fibrosis can be caused by a mutant form of the CFTR gene (dominant gene symbol is F and mutant is f). A. Using the rate of incidence above, what is the frequency of carriers of the cystic fibrosis allele for CFTR in the US? (3 pts) B. In a clinical study, 400 people from the population mentioned in (A.) were genotyped for BRCA1 Listed below are the results. Are these results in Hardy- Weinberg equilibrium? Use Chi Square to show whether or not they are. (3 pts) BRCA1 genotype # of women 390 BB Bb bb 10 0 12pt Paragraph L BIUAV V T² v V

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