FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
5th Edition
ISBN: 9781119661450
Author: Voet
Publisher: WILEY
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Chapter 22, Problem 23E
Summary Introduction
To explain: The way by which phosphofructokinase-2 activation by AMPK contributes to the antidiabetic effect of stimulating AMPK activity.
Concept introduction: AMPK is an AMP-dependent protein kinase, which is a major regulator of
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Chapter 22 Solutions
FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
Ch. 22 - Prob. 1ECh. 22 - Prob. 2ECh. 22 - 3. Toxins that occur in certain mushrooms block ?...Ch. 22 - Prob. 4ECh. 22 - 5. The passive glucose transporter named GLUT1...Ch. 22 - Prob. 6ECh. 22 - Prob. 7ECh. 22 - 8. (a) Identify the two reactions that allow the...Ch. 22 - Prob. 9ECh. 22 - Prob. 10E
Ch. 22 - Prob. 11ECh. 22 - 12. Predict the effect of an overdose of insulin...Ch. 22 - 13. Would you expect insulin to increase or...Ch. 22 - Prob. 14ECh. 22 - 15. Why can adipose tissue be considered to be an...Ch. 22 - 16. If the circulatory system of an ob/ob mouse is...Ch. 22 - 17. In experiments to test the...Ch. 22 - Prob. 18ECh. 22 - Prob. 19ECh. 22 - Prob. 20ECh. 22 - Prob. 22ECh. 22 - Prob. 21ECh. 22 - 23. AMPK activates phosphofructokinase-2. Explain...Ch. 22 - Prob. 24ECh. 22 - Prob. 25ECh. 22 - Prob. 26ECh. 22 - 27. Why does oxidative metabolism, which generates...Ch. 22 - Prob. 28CQCh. 22 - 29. Pancreatic ? cells express a receptor for...Ch. 22 - Prob. 30CQCh. 22 - Prob. 31CQCh. 22 - Prob. 32CQCh. 22 - 33. Experienced runners know that it is poor...Ch. 22 - 34. After several days of starvation, the capacity...Ch. 22 - Prob. 35CQCh. 22 - Prob. 36CQCh. 22 - Prob. 37CQCh. 22 - Prob. 38CQCh. 22 - Prob. 39CQCh. 22 - Prob. 40CQCh. 22 - Prob. 1MTE
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- 17. Which one of the compounds below is the major organic product obtained from the following series of reactions? CI benzyl alcohol OH PBr3 Mg 1. CO2 SOCl2 ? ether 2. H+, H₂O CI Cl HO OH CI Cl A B C D Earrow_forward14. What is the IUPAC name of this compound? A) 6-hydroxy-4-oxohexanenitrile B) 5-cyano-3-oxo-1-pentanol C) 5-cyano-1-hydroxy-3-pentanone D) 1-cyano-5-hydroxy-3-pentanone E) 5-hydroxy-3-oxopentanenitrile HO. CNarrow_forward13. What is the IUPAC name of this compound? A) 5-hydroxy-3,3-dimethylpentanoic acid B) 3,3-dimethylpentanoic acid C) 3,3-dimethyl-1-oxo-1,5-pentanediol D) 1,5-dihydroxy-3,3-dimethylpentanal E) 4-hydroxy-2,2-dimethylbutanoic acid HO OHarrow_forward
- Help me understand how carbon disulfide leads to toxicity in the brain, using terms like distal axonopathy, neurofilaments, covalent cross-linking, adducts, etc.,...please intuitively explain what is happening and where and the effects of it. For example, I know that CS2 reacts with amide and sulfhydryl groups on proteins, but what proteins exactly and where are they located?arrow_forwardWhat is the standard free energy change (in kJ/mole) of the spontaneous reaction between Oxygen and NADH to form H2O2 and NAD+?arrow_forwardRedox Chemistry: Give standard free energy changes expected for the following reactions:-Succinate -> fumarate (using FAD/FADH2)-Oxaloacetate -> Malate (using NAD/NADH)-NADH --> NAD+ (using FMN/FMNH2)-CoQ --> CoQH2 (using Cytochrome C)arrow_forward
- Give examples of balanced redox reactions that match the following:-Catabolic-Anabolic-Oxidative-Reductivearrow_forwardIf there are 20uM of a GLUT2 transporter on the surface of a cell, each able to move 8 per second, and 50mM glucose outside of the cell, what is the flux into the cell in mM/sec?arrow_forwardA transporter is responsible for antiporting calcium and glucose. The transporter brings glucose into the cell and sends calcium out of the cell. If blood [calcium] = 2.55mM and intracellular [calcium] = 7uM, blood [glucose] = 5.2mM, and intracellular [glucose] = 40uM, what is the free energy of transport? Assume a membrane potential of 62mV (negative inside).arrow_forward
- An ATP-coupled transporter is used to import 1 phosphate from the extracellular environment. Intracellular phosphate exists at 65mM, while it is 2mM outside.Assume a free energy change of ATP hydrolysis of -42.7 kJ/mol. What is the net free energy change of the coupled reaction? Assume a membrane potential of 70mV.arrow_forwardAnother transporter brings 3 chloride ions into the cell. Outside, chloride has a concentration of 107mM, and 4mM inside the cell. Assuming a membrane potential of 62mV (negative inside), what is the free energy of transport of these ions?arrow_forwardFor the Oxaloacetate -> Malate reaction, assume the normal ratio of NAD/NADH, what is the maximum ratio of Malate/Oxaloacetate that will allow reaction progress?arrow_forward
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