Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 18P
Human geneticists have found the Finnish population to be very useful for studies of a variety of conditions. The population is small; Finns have extensive church records documenting lineages; and few people have migrated into Finland. The frequency of some recessive disorders is higher in the Finnish population than elsewhere in the world, and diseases such as PKU and cystic fibrosis that are common elsewhere do not occur in the Finnish population.
| a. | How would a population geneticist explain these variations in disease occurrence? |
| b. | The Finnish population is also a source of information for the study of quantitative traits. The genetic basis of schizophrenia is one question that can be explored in this population. What advantage(s) and disadvantage(s) can you imagine for studying complex traits based on the Finnish population structure? |
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The human body is organized into a structural hierarchy that progresses from the macroscopic organismal level down to the microscopic chemical level. Each level builds upon the previous one, creating increasingly complex structures. Below is the hierarchy, from largest to smallest, with explanations linking each level to its predecessor:
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Chapter 22 Solutions
Genetics: From Genes to Genomes
Ch. 22 - Choose the best matching phrase in the right...Ch. 22 - Suppose you grew genetically identical dandelion...Ch. 22 - How can each of the following be used in...Ch. 22 - Two different groups of scientists studying a rare...Ch. 22 - Which of the following statements would be true of...Ch. 22 - Studies have indicated that for pairs of twins...Ch. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Table 22.2 lists concordance values for MZ and DZ...Ch. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Two alleles at one locus produce three distinct...Ch. 22 - In a certain plant, leaf size is determined by...Ch. 22 - Compare and contrast the use of SNP genotyping: i...Ch. 22 - Explain the similarities and differences between...Ch. 22 - In Fig. 22.14c, the fw2.2 causal gene was...Ch. 22 - Among the most prevalent pathologies that afflict...Ch. 22 - Human geneticists have found the Finnish...Ch. 22 - Canavan disease, caused by homozygosity for a...Ch. 22 - In GWAS analysis, because of the existence of LD...Ch. 22 - In Fig. 22.15: a. Why do some chromosomes in the...Ch. 22 - Consider the triangle diagram shown in Fig. 22.17....Ch. 22 - Prob. 23PCh. 22 - You conduct a Case/Control study comparing the...Ch. 22 - Prob. 25PCh. 22 - ALS amyotrophic lateral sclerosis is a rare, fatal...Ch. 22 - Through GWAS explorations, scientists have...Ch. 22 - In domesticated dogs, size has a high...Ch. 22 - Suppose a GWAS investigation found a particular LD...Ch. 22 - In 2008, Time magazine named as its invention of...
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