A&P Bundle
11th Edition
ISBN: 9780134761404
Author: Martini
Publisher: PEARSON
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Chapter 22, Problem 12CP
Summary Introduction
To identify:
Four major types of T-cells.
Introduction:
T-cells are one of the two types of lymphocytes along with B-cells produced in the human body. It is produced during hematopoiesis in the bone marrow and moves to thymus for further development and maturation. It is further categorized in four types.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
Chapter 22 Solutions
A&P Bundle
Ch. 22 - Define pathogen.Ch. 22 - Prob. 2CPCh. 22 - How would blockage of the thoracic duct affect...Ch. 22 - Prob. 4CPCh. 22 - Prob. 5CPCh. 22 - Prob. 6CPCh. 22 - Prob. 7CPCh. 22 - Prob. 8CPCh. 22 - Prob. 9CPCh. 22 - What effects do pyrogens have in the body?
Ch. 22 - Explain the difference between cell-mediated...Ch. 22 - Prob. 12CPCh. 22 - Prob. 13CPCh. 22 - Prob. 14CPCh. 22 - How can the presence of an abnormal peptide in the...Ch. 22 - A decrease in the number of cytotoxic T cells...Ch. 22 - How would a lack of helper T cells affect the...Ch. 22 - Prob. 18CPCh. 22 - Prob. 19CPCh. 22 - Prob. 20CPCh. 22 - Which would be more negatively affectedthe primary...Ch. 22 - Which kind of immunity protects a developing...Ch. 22 - How does increased stress reduce the effectiveness...Ch. 22 - Prob. 24CPCh. 22 - Prob. 25CPCh. 22 - What may account for the increased incidence of...Ch. 22 - Prob. 27CPCh. 22 - Prob. 28CPCh. 22 - LEVEL 1 Reviewing Facts and Terms 1. Identify the...Ch. 22 - Prob. 2RQCh. 22 - Anatomically, lymphatic vessels resemble (a)...Ch. 22 - Prob. 4RQCh. 22 - Prob. 5RQCh. 22 - Prob. 6RQCh. 22 - Phagocytes move through capillary walls by...Ch. 22 - Prob. 8RQCh. 22 - Prob. 9RQCh. 22 - Prob. 10RQCh. 22 - CD4 markers are associated with (a) cytotoxic T...Ch. 22 - Prob. 12RQCh. 22 - Prob. 13RQCh. 22 - What are the three classes of lymphocytes, and...Ch. 22 - What seven defenses present at birth provide the...Ch. 22 - Compared with innate defenses adaptive defenses...Ch. 22 - Prob. 17RQCh. 22 - A decrease in which population of lymphocytes...Ch. 22 - Skin tests are used to determine if a person (a)...Ch. 22 - Compare and contrast the effects of complement...Ch. 22 - How does a cytotoxic T cell destroy another cell...Ch. 22 - How does the formation of an antigen-antibody...Ch. 22 - Give one example of each type of immunity: innate...Ch. 22 - Prob. 24RQCh. 22 - An investigator at a crime scene discovers some...Ch. 22 - Ted finds out that he has been exposed to measles....Ch. 22 - While walking along the street, you and your...Ch. 22 - Paulas grandfather is diagnosed as having lung...Ch. 22 - Willy is allergic to ragweed pollen and tells you...Ch. 22 - Prob. 1CCCh. 22 - Does baby Ruthie still need her chickenpox vaccine...
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