Mechanisms for the three steps involved in the trapping of Î²- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the Î²- lactamase to open the Î²- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped Î²- lactamase product are to be proposed. Concept introduction: Three steps are involved in the conversion required. i ) Nucleophilic attack of Î²- lactamase on tazobactum to open the Î²- lactum ring ii) Formation of an imine intermediate by opening of the sulfur-containing ring in tazobactum iii) Cyclization to yield the trapped Î²- lactamase. All the three reactions involve the attack of nucleophiles. To propose: Mechanisms for the three steps involved in the trapping of Î²- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the Î²- lactamase to open the Î²- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped Î²- lactamase product.

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Chapter 21.SE, Problem 42MP

Interpretation Introduction

Interpretation:

Mechanisms for the three steps involved in the trapping of Î²- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the Î²- lactamase to open the Î²- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped Î²- lactamase product are to be proposed.

Concept introduction:

Three steps are involved in the conversion required. i ) Nucleophilic attack of Î²- lactamase on tazobactum to open the Î²- lactum ring ii) Formation of an imine intermediate by opening of the sulfur-containing ring in tazobactum iii) Cyclization to yield the trapped Î²- lactamase. All the three reactions involve the attack of nucleophiles.

To propose:

Mechanisms for the three steps involved in the trapping of Î²- lactamase by tazobactum such as a) the reaction of the hydroxyl group on the Î²- lactamase to open the Î²- lactum ring of tazobactum b) The opening of the sulfur-containing ring in tazobactum to give an acyclic imine intermediate c) Cyclization of the imine intermediate to yield trapped Î²- lactamase product.

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