Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate, 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate.2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH, are to be proposed. Concept introduction: All the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate take place through two steps i) Attack of a nucleophile on either P or C and ii) Elimination of the leaving group. To propose: Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate 2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH.

Question

Would the following organic synthesis occur in one step? Add any missing products, required catalysts, inorganic reagents, and other important conditions. Please include a detailed explanation and drawings showing how the reaction may occur in one step.

Answer 1

Question

Chapter 21.SE, Problem 41MP

Interpretation Introduction

Interpretation:

Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate, 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate.2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH, are to be proposed.

Concept introduction:

All the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate take place through two steps i) Attack of a nucleophile on either P or C and ii) Elimination of the leaving group.

To propose:

Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate 2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH.

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