Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate, 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate.2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH, are to be proposed. Concept introduction: All the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate take place through two steps i) Attack of a nucleophile on either P or C and ii) Elimination of the leaving group. To propose: Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate 2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH.

Question

A. B. b. Now consider the two bicyclic molecules A. and B. Note that A. is a dianion and B. is a neutral molecule. One of these molecules is a highly reactive compound first characterized in frozen noble gas matrices, that self-reacts rapidly at temperatures above liquid nitrogen temperature. The other compound was isolated at room temperature in the early 1960s, and is a stable ligand used in organometallic chemistry. Which molecule is the more stable molecule, and why?

Answer 1

Question

Chapter 21.SE, Problem 41MP

Interpretation Introduction

Interpretation:

Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate, 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate.2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH, are to be proposed.

Concept introduction:

All the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate take place through two steps i) Attack of a nucleophile on either P or C and ii) Elimination of the leaving group.

To propose:

Mechanisms for the three steps involved in the conversion of 3-phosphoglycerate into glyceraldehyde-3-phosphate 1) Phosphorylation of 3-phosphoglycerate by treating with ATP to form 1,3- bisphosphoglycerate 2) Reaction of 1,3- bisphosphoglycerate with the thiol group on the enzyme to give an enzyme-bound thioester 3) Reduction of the enzyme bound thioester with NADH.

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A. B. b. Now consider the two bicyclic molecules A. and B. Note that A. is a dianion and B. is a neutral molecule. One of these molecules is a highly reactive compound first characterized in frozen noble gas matrices, that self-reacts rapidly at temperatures above liquid nitrogen temperature. The other compound was isolated at room temperature in the early 1960s, and is a stable ligand used in organometallic chemistry. Which molecule is the more stable molecule, and why?

Where are the chiral centers in this molecule? Also is this compound meso yes or no?

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