NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
9th Edition
ISBN: 9781265432287
Author: Anderson
Publisher: MCG CUSTOM
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Chapter 21, Problem 6SA
Summary Introduction
To review:
A mechanism by which Klebsiellapneumoniae become antibiotic resistant.
Introduction:
Klebsiellapneumoniae can cause many diseases, one of them is pneumonia. It is responsible for diseases of the lower respiratory tract. The Klebsiella-infected diseases are mostly hospitalborne. These bacteria can show multidrug resistance. They contain a plasmid-encodedbeta-lactamase that is responsible for the inactivation of the beta-lactam groups of antibiotics (majorly the penicillins).
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 21 Solutions
NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
Ch. 21 - Prob. 1SACh. 21 - After you recover from strep throat, can you get...Ch. 21 - Prob. 3SACh. 21 -
4. Why has no vaccine been developed for the...Ch. 21 - Prob. 5SACh. 21 - Prob. 6SACh. 21 - Prob. 7SACh. 21 - Prob. 8SACh. 21 - Why did it take so long to discover the cause of...Ch. 21 - Prob. 10SA
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