NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
9th Edition
ISBN: 9781265432287
Author: Anderson
Publisher: MCG CUSTOM
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Chapter 21, Problem 7SA
Summary Introduction
To review:
The reason behind the prompt rise in incidences of whooping cough when pertussis immunizations were stopped.
Introduction:
Whooping cough is a contagious bacterial disease. Pertussis is the common name for the disease “whooping cough” that is caused by Bordetella pertussis. The use of vaccines reduced the cases of the disease sharply. Primarily, the whole organism was used to make the vaccine, but due to several side effects of severe kind, this vaccine was barred from use.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 21 Solutions
NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
Ch. 21 - Prob. 1SACh. 21 - After you recover from strep throat, can you get...Ch. 21 - Prob. 3SACh. 21 -
4. Why has no vaccine been developed for the...Ch. 21 - Prob. 5SACh. 21 - Prob. 6SACh. 21 - Prob. 7SACh. 21 - Prob. 8SACh. 21 - Why did it take so long to discover the cause of...Ch. 21 - Prob. 10SA
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