The synthesis of propranolol has to be shown from 1-naphthol.

Question

You are trying to decide if there is a single reagent you can add that will make the following synthesis possible without any other major side products: xi 1. ☑ 2. H₂O хе i Draw the missing reagent X you think will make this synthesis work in the drawing area below. If there is no reagent that will make your desired product in good yield or without complications, just check the box under the drawing area and leave it blank. Click and drag to start drawing a structure. There is no reagent that will make this synthesis work without complications. : ☐ S ☐

Answer 1

Question

Chapter 21, Problem 21.58P

(a)

Interpretation Introduction

Interpretation:

The synthesis of propranolol has to be shown from 1-naphthol.

(b)

Interpretation Introduction

Interpretation:

The chirality of Propranolol is to be identified and the possible stereoisomers has to be identified in the given synthesis.

Concept introduction:

Chiral:

A molecule is non superimposable on its mirror image is called chiral molecule.

Four different atoms attached to a carbon atom is called chiral molecule.

Isomer:

A molecule having the same molecular formula but with different chemical structure is called isomer.

Stereoisomers:

Stereoisomers are molecules that have the same molecular formula and they differ only in arrangement of atom in three-dimensional space.

Enantiomers:

A compound which is non-superimposable mirror image is called enantiomers.

Diastereomers:

A compound which is non-superimposable and non-mirror image is called diastereomers.

Racemic mixture:

A racemic mixture is simply a mixture containing an equal amount of each enantiomer.

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