Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 21, Problem 1PDQ
HOW DO WE KNOW? In this chapter, we focused on the analysis of genomes, transcriptomes, and proteomes and considered important applications and findings from these endeavors. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions?
- (a) How do we know which contigs are part of the same chromosome?
- (b) How do we know if a genomic DNA sequence contains a protein-coding gene?
- (c) What evidence supports the concept that humans share substantial sequence similarities and gene functional similarities with model organisms?
- (d) How can proteomics identify differences between the number of protein-coding genes predicted for a genome and the number of proteins expressed by a genome?
- (e) How has the concept of a reference genome evolved to encompass a broader understanding of genomic variation in humans?
- (f) How have microarrays demonstrated that, although all cells of an organism have the same genome, some genes are expressed in almost all cells, whereas other genes show cell- and tissue-specific expression?
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Chapter 21 Solutions
Concepts of Genetics (11th Edition)
Ch. 21 - In a sequence encompassing 99.4 percent of the...Ch. 21 - Annotation of a proteome attempts to relate each...Ch. 21 - Because of its accessibility and biological...Ch. 21 - Prob. 1CSCh. 21 - Prob. 2CSCh. 21 - Prob. 3CSCh. 21 - HOW DO WE KNOW? In this chapter, we focused on the...Ch. 21 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 21 - What is functional genomics? How does it differ...Ch. 21 - Compare and contrast WGS to a map-based cloning...
Ch. 21 - What is bioinformatics, and why is this discipline...Ch. 21 - Describe three major goals of the Human Genome...Ch. 21 - Prob. 7PDQCh. 21 - BLAST searches and related applications are...Ch. 21 - Prob. 9PDQCh. 21 - Describe the human genome in terms of genome size,...Ch. 21 - What functional information about a genome can be...Ch. 21 - The Human Genome Project has demonstrated that in...Ch. 21 - Annotation involves identifying genes and...Ch. 21 - Through the Human Genome Project (HGP), a...Ch. 21 - Describe the significance of the Genome 10K...Ch. 21 - Prob. 16PDQCh. 21 - Prob. 17PDQCh. 21 - What are DNA microarrays? How are they used?Ch. 21 - Prob. 19PDQCh. 21 - Prob. 20PDQCh. 21 - Prob. 21ESPCh. 21 - Prob. 22ESPCh. 21 - Prob. 23ESPCh. 21 - Homology can be defined as the presence of common...Ch. 21 - Prob. 25ESPCh. 21 - Prob. 26ESPCh. 21 - Prob. 27ESPCh. 21 - Whole-exome sequencing (WES) is helping physicians...
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